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SHOX2

Official Full Name

short stature homeobox 2
Overview

This gene is a member of the homeobox family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeobox genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeobox genes. This locus represents a pseudoautosomal homeobox gene that is thought to be responsible for idiopathic short stature, and it is implicated in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants.
Synonyms

SHOX2; short stature homeobox 2; short stature homeobox protein 2; OG12; OG12X; SHOT; Homeobox protein Og12X; OG 12; OG 12X; OGI 2X; OGI2X; Paired related homeobox protein SHOT; Paired-related homeobox protein SHOT; Short stature homeobox homolog; SHOX 2; SHOX homologous gene on chromosome 3; SHOX2_HUMAN; OTTHUMP00000213397; OTTHUMP00000213398; OTTHUMP00000213399; OTTHUMP00000245277;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Wheat Germ

Tag

His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SHOX2-31358TH	Recombinant Human SHOX2	Wheat Germ	N/A	88 amino acids	Inquiry
Human	SHOX2-2665H	Recombinant Human SHOX2, His-tagged	E.coli	His	1-355aa	$319 / 25ug
Human	SHOX2-1604HCL	Recombinant Human SHOX2 cell lysate		N/A		Inquiry
Mouse	SHOX2-15111M	Recombinant Mouse SHOX2 Protein	Mammalian Cell	His		Inquiry
Mouse	Shox2-5870M	Recombinant Mouse Shox2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	SHOX2-8160M-B	Recombinant Mouse SHOX2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	SHOX2-8160M	Recombinant Mouse SHOX2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	SHOX2-5395R	Recombinant Rat SHOX2 Protein	Mammalian Cell	His		Inquiry
Rat	SHOX2-5054R-B	Recombinant Rat SHOX2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	SHOX2-5054R	Recombinant Rat SHOX2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	SHOX2-11413Z	Recombinant Zebrafish SHOX2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

SHOX2 involved in several pathways and played different roles in them. We selected most pathways SHOX2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SHOX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

SHOX2 has several biochemical functions, for example, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHOX2 itself. We selected most functions SHOX2 had, and list some proteins which have the same functions with SHOX2. You can find most of the proteins on our site.

Function	Related Protein
sequence-specific DNA binding	SPI1A;TA;HOXD10A;TAF2;UBP1;Trl;FOXI1;ISL2;NKX6.2

SHOX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHOX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SHOX2.

CDK4