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SI

Official Full Name

sucrase-isomaltase (alpha-glucosidase)
Overview

This gene encodes a sucrase-isomaltase enzyme that is expressed in the intestinal brush border. The encoded protein is synthesized as a precursor protein that is cleaved by pancreatic proteases into two enzymatic subunits sucrase and isomaltase. These two subunits heterodimerize to form the sucrose-isomaltase complex. This complex is essential for the digestion of dietary carbohydrates including starch, sucrose and isomaltose. Mutations in this gene are the cause of congenital sucrase-isomaltase deficiency.
Synonyms

SI; sucrase-isomaltase (alpha-glucosidase); sucrase isomaltase; sucrase-isomaltase, intestinal; Oligosaccharide alpha 1; 6 glucosidase; Isomaltase; MGC131621; MGC131622; Oligosaccharide alpha 1, 6 glucosidase; sucrase isomaltase alpha glucosidase; SUIS_HUMAN; OTTHUMP00000212594; oligosaccharide alpha-1,6-glucosidase;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Rat

Source

Baculovirus-Insect cells
E.coli
HEK293
In vitro E. coli expression system
Mammalian Cell
Wheat Germ

Tag

C
His
His (Fc)
Avi
His|S
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SI-7918H	Recombinant Human SI protein, His & S-tagged	E.coli	His/S	Asn1717~Ser1827 (Accession # P14410)	Inquiry
Human	SI-29814TH	Recombinant Human SI	Wheat Germ	N/A	99 amino acids	Inquiry
Human	SI-0516H	Recombinant Human SI Protein (Lys62-Trp931), C-His-tagged	Baculovirus-Insect cells	C-His	Lys62-Trp931	Inquiry
Human	SI-0515H	Recombinant Human SI Protein (Asn932-Ser1827), C-His-tagged	Baculovirus-Insect cells	C-His	Asn932-Ser1827	Inquiry
Human	SI-193H	Recombinant Human SI Transmembrane protein, His-tagged	In vitro E. coli expression system	His	2-1007aa	Inquiry
Human	SI-6289H	Recombinant Human SI Protein (Asn932-Ser1827), C-His tagged	E.coli	C-His	Asn932-Ser1827	Inquiry
Rat	SI-5396R	Recombinant Rat SI Protein	Mammalian Cell	His		Inquiry
Rat	SI-5055R-B	Recombinant Rat SI Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	SI-5055R	Recombinant Rat SI Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SI Related Articles

SI involved in several pathways and played different roles in them. We selected most pathways SI participated on our site, such as Galactose metabolism, Starch and sucrose metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with SI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Galactose metabolism	AKR1B7;GANC;Akr1b3;HK3;GALM;AKR1B1;HK1;HK2;G6PC2
Starch and sucrose metabolism	UGT1A3;UGP2A;AGL;HK1;GPIB;GAA;PYGB;TREH;GANC
Metabolic pathways	PNP6;MTHFD1B;NMRK2;ALG10;GOT2;ASMT;MAPK1IP1L;DHRS4;AOC2
Carbohydrate digestion and absorption	AMY2A5;TAS1R2;ATP1B3;HK2;SI;HK3;PIK3CA;PIK3CG;TAS1R3

SI has several biochemical functions, for example, alpha-1,4-glucosidase activity, carbohydrate binding, oligo-1,6-glucosidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SI itself. We selected most functions SI had, and list some proteins which have the same functions with SI. You can find most of the proteins on our site.

Function	Related Protein
alpha-1,4-glucosidase activity	GANC;SI
carbohydrate binding	CLEC4A;CNTN1;GALNT1;CLEC6A;MAN2B2;PKD1L3;CHIA;KRT1;LPHN1
oligo-1,6-glucosidase activity
sucrose alpha-glucosidase activity

SI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SI here. Most of them are supplied by our site. Hope this information will be useful for your research of SI.

Ko, KI; Coimbra, LS; et al. Diabetes reduces mesenchymal stem cells in fracture healing through a TNF alpha-mediated mechanism. DIABETOLOGIA 58:633-642(2015).

Nguyen, AT; van Doorn, R; et al. Flow-Through Microbial Capture by Antibody-Coated Microsieves. ADVANCED MATERIALS INTERFACES 2:-(2015).