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SIAE

  • Official Full Name

    sialic acid acetylesterase

  • Overview

    This gene encodes an enzyme which removes 9-O-acetylation modifications from sialic acids. Mutations in this gene are associated with susceptibility to autoimmune disease 6. Multiple transcript variants encoding different isoforms, found either in the cytosol or in the lysosome, have been found for this gene.
  • Synonyms

    SIAE; sialic acid acetylesterase; YSG2, Ysg2 homolog (mouse); sialate O-acetylesterase; CSE C; LSE; MGC87009; sialic acid specific acetylesterase II; CSEC; Cytosolic sialic acid 9 O acetylesterase homolog; H Lse; HLse; Sialate O acetylesterase; Sialic acid specific 9 O acetylesterase; YSG2; Ysg2 homolog; H-Lse; sialic acid-specific acetylesterase II; cytosolic sialic acid 9-O-acetylesterase homolog; AIS6; CSE-C;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Flag
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • N/A
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SIAE-7357H Recombinant Human SIAE, His tagged Insect Cell His
Human SIAE-189H Recombinant Human SIAE, His-tagged HEK293 His
Human SIAE-001HCL Recombinant Human SIAE cell lysate Insect Cell N/A
Human SIAE-2007H Recombinant Human SIAE Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SIAE-2007H-B Recombinant Human SIAE Protein Pre-coupled Magnetic Beads HEK293
Human SIAE-694H Recombinant Human SIAE Protein, His/GST-tagged E.coli His/GST Ala22~Pro244
Human SIAE-5930H Recombinant Human SIAE Protein (Ile24-Lys523), C-His tagged Mammalian cells C-His Ile24-Lys523
Human SIAE-5931H Recombinant Human SIAE Protein (Ala22-Pro244), N-GST tagged E.coli N-GST Ala22-Pro244
Human SIAE-1472HFL Recombinant Full Length Human SIAE Protein, C-Flag-tagged Mammalian cells Flag
Mouse SIAE-15119M Recombinant Mouse SIAE Protein Mammalian Cell His
Mouse SIAE-110M Recombinant Mouse SIAE Protein, his-tagged HEK293 His
Mouse Siae-5873M Recombinant Mouse Siae Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse SIAE-8167M-B Recombinant Mouse SIAE Protein Pre-coupled Magnetic Beads HEK293
Mouse SIAE-8167M Recombinant Mouse SIAE Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SIAE-4199R Recombinant Rhesus monkey SIAE Protein, His-tagged Mammalian Cell His
Rhesus Macaque SIAE-4015R-B Recombinant Rhesus Macaque SIAE Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SIAE-4015R Recombinant Rhesus Macaque SIAE Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish SIAE-3872Z Recombinant Zebrafish SIAE Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SIAE Related Articles

SIAE involved in several pathways and played different roles in them. We selected most pathways SIAE participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SIAE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

SIAE has several biochemical functions, for example, sialate O-acetylesterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIAE itself. We selected most functions SIAE had, and list some proteins which have the same functions with SIAE. You can find most of the proteins on our site.

Function Related Protein
sialate O-acetylesterase activity

SIAE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIAE here. Most of them are supplied by our site. Hope this information will be useful for your research of SIAE.

cona_canen

Yamamoto, M; Iguchi, G; et al. A missense single-nucleotide polymorphism in the sialic acid acetylesterase (SIAE) gene is associated with anti-PIT-1 antibody syndrome. ENDOCRINE JOURNAL 61:641-644(2014).
Pituch-Noworolska, A; Blaut-Szlosarczyk, A; et al. Occurrence of autoantibodies for gastrointestinal autoimmune diseases in children with common variable immune deficiency and selected IgA deficiency. PRZEGLAD GASTROENTEROLOGICZNY 8:370-376(2013).
Speletas, M; Sevdali, E; et al. SIALIC ACID ACETYLESTERASE (SIAE) MUTATIONS ARE NOT ASSOCIATED WITH AUTOIMMUNE DISEASE RISK IN PATIENTS WITH ANTIBODY DEFICIENCIES. JOURNAL OF CLINICAL IMMUNOLOGY 32:403-404(2012).
Pillai, S; Mattoo, H; et al. B cells and autoimmunity. CURRENT OPINION IN IMMUNOLOGY 23:721-731(2011).
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