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SIGLEC5

  • Official Full Name

    sialic acid binding Ig-like lectin 5

  • Overview

    This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface;lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition;sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits;the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B;Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.
  • Synonyms

    SIGLEC5; sialic acid binding Ig-like lectin 5; CD33L2; sialic acid-binding Ig-like lectin 5; CD170; OB BP2; SIGLEC 5; CD33 antigen-like 2; OB-binding protein 2; obesity-binding protein 2; sialic acid-binding immunoglobulin-like lectin 5; OBBP2; OB-BP2; SI;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Rhesus monkey
  • E. coli
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Mammalian cells
  • C
  • Fc
  • Avi
  • His
  • HIgG
  • His (Fc)
  • His|S
  • human|IgG1|Fc
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SIGLEC5-941H Active Recombinant Human SIGLEC5 Protein, Fc Chimera Mammalian cells Fc
Human SIGLEC5-7330H Recombinant Human SIGLEC5 protein, Fc-tagged HEK293 human/IgG1/Fc Glu17-Thr434
Human SIGLEC5-428H Recombinant Human SIGLEC5 Protein HEK293 N/A Met1-Thr 434
Human SIGLEC5-5674H Recombinant Human SIGLEC5 protein, His & S-tagged E.coli His/S Asp147~Pro335 (Accession # O15389)
Human SIGLEC5-1505HCL Recombinant Human SIGLEC5 cell lysate Human Cell N/A
Human SIGLEC5-1075HCL Recombinant Human SIGLEC5 cell lysate Human Cell N/A
Human SIGLEC5-5941H Recombinant Human SIGLEC5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SIGLEC5-34H Recombinant Human SIGLEC5 Protein (17-441), C-Fc/Avi-tagged, Biotin-labeled HEK293 C-Fc/Avi 17-441
Human SIGLEC5-01H Recombinant Human SIGLEC5 Protein, hIgG-His-Tagged Insect Cell HIgG/His 667aa
Human SIGLEC5-098H Recombinant Human SIGLEC5 protein, His-Avi-tagged HEK293 His-Avi lt contains Glu17-Thr434.
Human SIGLEC5-514H Recombinant Human SIGLEC5 protein, His-tagged E. coli His 241-442 aa
Human SIGLEC5-0725H Recombinant Human SIGLEC5 protein, Fc-tagged HEK293 Fc Glu17-Thr434
Human SIGLEC5-153H Recombinant Human SIGLEC5 Protein, C-His-tagged E.coli C-His
Human SIGLEC5-0941H Recombinant Human SIGLEC5 Protein (Phe458-Lys551), N-His tagged E.coli N-His Phe458-Lys551
Human SIGLEC5-2689H Recombinant Human SIGLEC5 Protein, His-tagged E.coli N-His Pro19-Leu441
Human SIGLEC5-5240H Recombinant Human SIGLEC5 Protein (Met1-Thr434), C-His tagged Mammalian cells C-His Met1-Thr434
Human SIGLEC5-445H Recombinant Human SIGLEC5 Protein, Fc-tagged HEK293 Fc 551
Human SIGLEC5-142H Recombinant Human SIGLEC5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SIGLEC5-35H Recombinant Human SIGLEC5 Protein (17-441), C-Fc/Avi-tagged HEK293 C-Fc/Avi 17-441
Human SIGLEC5-142H-B Recombinant Human SIGLEC5 Protein Pre-coupled Magnetic Beads HEK293
Rhesus monkey SIGLEC5-1596R Recombinant Rhesus Monkey SIGLEC5 Protein HEK293 N/A
Homo sapiens (Human) RFL17020HF Recombinant Full Length Human Sialic Acid-Binding Ig-Like Lectin 5(Siglec5) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (17-551)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SIGLEC5 Related Research Area

SIGLEC5 involved in several pathways and played different roles in them. We selected most pathways SIGLEC5 participated on our site, such as Adaptive Immune System, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIGLEC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemDYNC1LI2;RAPGEF4;ASB2;RACGAP1;ITGB1B.1;KIF2C;ASB17;AMICA1;RAP1GAP2
Immune SystemBTR09;DYNLL2;PJA1;CYLD;CSHL1;EVL;KIF5B;ASB9;DEFB106A
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellSIGLEC5;LILRB4;TREM1;SIGLEC9;CRTAM;CD300LG;SIGLEC12;SIGLEC8;CD200R2

SIGLEC5 has several biochemical functions, for example, carbohydrate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIGLEC5 itself. We selected most functions SIGLEC5 had, and list some proteins which have the same functions with SIGLEC5. You can find most of the proteins on our site.

Function Related Protein
carbohydrate bindingCHIA;ZG16;GALNT12;CLEC18B;CHI3L2;GALNT5;CANX;LGALS9L1;SIGLEC5
protein bindingPARL;TLR1;ZBTB16;UQCC1;CD72;FGD5;PA2G4;MLANA;CCDC103

SIGLEC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIGLEC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIGLEC5.

TRIP13; VAC14; q7cjv9_yerpe

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