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SLC11A2

Official Full Name

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
Overview

This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

SLC11A2; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2; NRAMP2; natural resistance-associated macrophage protein 2; DCT1; DMT1; DMT-1; NRAMP 2; divalent cation transporter 1; FLJ37416;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque
Zebrafish

Source

E. coli
E.coli
HEK293
Insect Cell
Mammalian Cell

Tag

8His
MBP,Flag
GST
His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SLC11A2-2696H	Recombinant Human SLC11A2, GST-tagged	E.coli	GST	1-80aa	$319 / 25ug
Human	SLC11A2-152H	Recombinant Human SLC11A2 protein, His-tagged	E. coli	His	1-80 aa	$319 / 25ug
Human	SLC11A2-0560H	Recombinant Human SLC11A2 Protein (V2-R568), 8×His-MBP, Flag tagged	Insect Cell	8His-MBP,Flag	V2-R568	Inquiry
Mouse	SLC11A2-15206M	Recombinant Mouse SLC11A2 Protein	Mammalian Cell	His		Inquiry
Mouse	SLC11A2-8215M	Recombinant Mouse SLC11A2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	SLC11A2-8215M-B	Recombinant Mouse SLC11A2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	SLC11A2-4218R	Recombinant Rhesus monkey SLC11A2 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	SLC11A2-4034R-B	Recombinant Rhesus Macaque SLC11A2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	SLC11A2-4034R	Recombinant Rhesus Macaque SLC11A2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	SLC11A2-3791Z	Recombinant Zebrafish SLC11A2	Mammalian Cell	His		Inquiry
Chicken	SLC11A2-3846C	Recombinant Chicken SLC11A2	Mammalian Cell	His		Inquiry
Chicken	SLC11A2-3847C	Recombinant Chicken SLC11A2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SLC11A2 Related Articles

SLC11A2 involved in several pathways and played different roles in them. We selected most pathways SLC11A2 participated on our site, such as Lysosome, Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC11A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Lysosome	DNASE2;CTSL1B;ASAH1B;LGMN;SGSH;GLA;HEXA;SLC11A1;GGA1
Mineral absorption	ATP7A;MT1E;FXYD2;MT2;MT1X;ATP2B1;SLC5A1;SLC26A9;ATP1B1

SLC11A2 has several biochemical functions, for example, cadmium ion binding, cadmium ion transmembrane transporter activity, NOT calcium ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC11A2 itself. We selected most functions SLC11A2 had, and list some proteins which have the same functions with SLC11A2. You can find most of the proteins on our site.

Function	Related Protein
cadmium ion binding	NOS3;MT3;NOS1;SLC11A2;P2RX2
cadmium ion transmembrane transporter activity
NOT calcium ion transmembrane transporter activity
NOT chromium ion transmembrane transporter activity
cobalt ion binding	SLC11A2;P2RX2;BIRC5;PML;NUDT16
cobalt ion transmembrane transporter activity	SLC11A2;MMGT2
copper ion binding	S100A12;HEPH;PRND;TP53;ATP7B;ADNP;LOXL5B;AOC2;CCS
copper ion transmembrane transporter activity	SLC11A2;SLC31A2;ATP7A;ATOX1;MMGT2;SLC31A1
ferrous iron transmembrane transporter activity	SLC11A2;SLC40A1;SLC39A14
ferrous iron uptake transmembrane transporter activity
hydrogen ion transmembrane transporter activity	ATP6V0A1B;ATP5G3A;ATP6V0A2B;ATP6V1B1;ATP5G3;ATPV0E2;ATP5J;ATP6V1F;ATP5I
inorganic cation transmembrane transporter activity	SLC39A1;SLC11A2;MMGT2
iron ion binding	CYP2J5;CYP4V7;CYP8B2;LEPREL2;CYP2P6;CYP26B1;PLOD2;CYP4V8;CYP21A2
lead ion transmembrane transporter activity
manganese ion binding	PPM1M;PPM1A;FAM20C;PPM1BB;ABL1;B4GALT7;XPNPEP3;TDP2B;ME1
manganese ion transmembrane transporter activity	SLC11A2;ZP3;TRPM2;SLC11A1;MMGT2
nickel cation binding	SLC11A2;CA3;CAR3;P2RX2
nickel cation transmembrane transporter activity	MMGT2;SLC11A2
protein binding	ALX1;TBX22;GADD45A;UBE2R2;DDX11;ATXN7L1;LMO4;TRAPPC2L;MAPK11
solute:proton symporter activity	SLC33A1;SLC11A2;MFSD3
transferrin transmembrane transporter activity	SLC11A2;TFRC
transition metal ion transmembrane transporter activity	SLC11A1;SLC11A2
vanadium ion transmembrane transporter activity
zinc ion binding	GATA2;TAF3;CBLB;NHLRC1;CIZ1B;CYLD;GATA1;ZEB1;LIMA1
zinc ion transmembrane transporter activity	SLC39A11;SLC30A6;SLC30A10;SLC30A5;SLC30A1A;SLC30A1;SLC30A2;SLC30A7;SLC39A2
NOT zinc ion transmembrane transporter activity

SLC11A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC11A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC11A2.

MT-CO2; b3xyc5_sollc

Latunde-Dada, GO; Pereira, DIA; et al. A Nanoparticulate Ferritin-Core Mimetic Is Well Taken Up by HuTu 80 Duodenal Cells and Its Absorption in Mice Is Regulated by Body Iron. JOURNAL OF NUTRITION 144:1896-1902(2014).

Garrick, MD; Kuo, HC; et al. Comparison of mammalian cell lines expressing distinct isoforms of divalent metal transporter 1 in a tetracycline-regulated fashion. BIOCHEMICAL JOURNAL 398:539-546(2006).