SLC12A6
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Official Full Name
solute carrier family 12 (potassium/chloride transporters), member 6
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Overview
This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. -
Synonyms
SLC12A6; solute carrier family 12 (potassium/chloride transporters), member 6; ACCPN, agenesis of corpus callosum and peripheral neuropathy (Andermann syndrome) , KCC3; solute carrier family 12 member 6; ACCPN; Furosemide sensitive KCl cotransporter 3; Gaxp; KCC 3; KCC 3A; KCC 3B; KCC3 A; KCC3; KCC3 B; KCC3A; KCC3B; Potassium chloride cotransporter 3; Potassium chloride cotransporter KCC3a S3; SLC12 A6; SLC12A 6; Solute carrier family 12, member 6; OTTHUMP00000159813; K-Cl cotransporter 3; potassium-chloride transporter-3a; potassium-chloride transporter-3b; potassium chloride cotransporter KCC3a-S3; electroneutral potassium-chloride cotransporter 3;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | SLC12A6-1728H | Recombinant Human SLC12A6 protein, His & GST-tagged | E.coli | His/GST | Glu559~Ser735 (Accession # Q9UHW9) |
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- SLC12A6 Related Research Area
SLC12A6 involved in several pathways and played different roles in them. We selected most pathways SLC12A6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC12A6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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SLC12A6 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by SLC12A6 itself. We selected most functions SLC12A6 had, and list some proteins which have the same functions with SLC12A6. You can find most of the proteins on our site.
| Function | Related Protein |
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SLC12A6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC12A6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC12A6.
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