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SLC19A2

Official Full Name

solute carrier family 19 (thiamine transporter), member 2
Overview

This gene encodes the thiamin transporter protein. Mutations in this gene cause thiamin-responsive megaloblastic anemia syndrome (TRMA), which is an autosomal recessive disorder characterized by diabetes mellitus, megaloblastic anemia and sensorineural deafness.
Synonyms

SLC19A2; solute carrier family 19 (thiamine transporter), member 2; TRMA; thiamine transporter 1; THTR1; S19A2_HUMAN; Solute carrier family 19 member 2; TC1; Thiamine carrier 1; THT1; ThTr 1; ThTr-1; OTTHUMP00000033497; OTTHUMP00000033498; OTTHUMP00000033499; high affinity thiamine transporter; reduced folate carrier protein (RFC) like;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SLC19A2-1617HCL	Recombinant Human SLC19A2 cell lysate		N/A		Inquiry
Human	SLC19A2-0523H	Recombinant Human SLC19A2 Protein (D2-S497), 8×His-Strep, Flag tagged	Insect Cell	8His-Strep,Flag	D2-S497	Inquiry
Rhesus Macaque	SLC19A2-4227R	Recombinant Rhesus monkey SLC19A2 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	SLC19A2-4043R	Recombinant Rhesus Macaque SLC19A2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	SLC19A2-4043R-B	Recombinant Rhesus Macaque SLC19A2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

SLC19A2 involved in several pathways and played different roles in them. We selected most pathways SLC19A2 participated on our site, such as Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC19A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Metabolism	CKBA;DPYD;UGT1B2;MED23;PDK2B;CYP51A1;ADSS;SLC27A5;UPP2
Metabolism of vitamins and cofactors	CD320;SLC2A3;TCN1;PDZD11;SLC25A32;SLC5A6B;SLC5A6A;SLC23A2;GPHN
Metabolism of water-soluble vitamins and cofactors	CBLC-1;SLC5A6A;SLC23A2;ELA2L;GSTO2;SLC25A32A;SLC2A3;PDZD11;TCN1
Vitamin B1 (thiamin) metabolism
Vitamin digestion and absorption	BTD;GIF;PNLIP;CUBN;LMBRD1;LRAT;RBP2;TCN2;MMACHC

SLC19A2 has several biochemical functions, for example, folic acid transporter activity, protein binding, thiamine transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC19A2 itself. We selected most functions SLC19A2 had, and list some proteins which have the same functions with SLC19A2. You can find most of the proteins on our site.

Function	Related Protein
folic acid transporter activity	SLC46A1;SLC25A32;SLC19A1;SLC19A2;DAAM2;FOLR1;FOLR2
protein binding	VTN;SLC6A20B;KRT4;PI4K2A;PEX26;URI1;AMIGO2;CD164;CASP10
thiamine transmembrane transporter activity
thiamine uptake transmembrane transporter activity	SLC19A3B;SLC19A3;C2orf83;SLC19A2

SLC19A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC19A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC19A2.

CERS2