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SLC22A1

  • Official Full Name

    solute carrier family 22 (organic cation transporter), member 1

  • Overview

    Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.
  • Synonyms

    SLC22A1; solute carrier family 22 (organic cation transporter), member 1; solute carrier family 22 member 1; OCT1; organic cation transporter 1; HOCT1; oct1_cds;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SLC22A1-6823HF Recombinant Full Length Human SLC22A1 Protein, GST-tagged In Vitro Cell Free System GST 1049 amino acids
Human SLC22A1-677H Recombinant Human SLC22A1 Protein Wheat Germ N/A
Mouse SLC22A1-15261M Recombinant Mouse SLC22A1 Protein Mammalian Cell His
Mouse SLC22A1-8255M-B Recombinant Mouse SLC22A1 Protein Pre-coupled Magnetic Beads HEK293
Mouse SLC22A1-8255M Recombinant Mouse SLC22A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SLC22A1-5451R Recombinant Rat SLC22A1 Protein Mammalian Cell His
Rat SLC22A1-5110R Recombinant Rat SLC22A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SLC22A1-5110R-B Recombinant Rat SLC22A1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SLC22A1 Related Research Area

SLC22A1 involved in several pathways and played different roles in them. We selected most pathways SLC22A1 participated on our site, such as Bile secretion, Choline metabolism in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC22A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Bile secretionHMGCR;ABCB1A;GNAS;ATP1A1;ATP1A4;SLC22A7;ADCY9;SLC9A1;AQP9
Choline metabolism in cancerPIK3R5;SLC22A5;WASF1;SLC5A7;PLA2G4C;CHKB;PIK3R1;DGKZ;DGKQ

SLC22A1 has several biochemical functions, for example, acetylcholine transmembrane transporter activity, dopamine transmembrane transporter activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC22A1 itself. We selected most functions SLC22A1 had, and list some proteins which have the same functions with SLC22A1. You can find most of the proteins on our site.

Function Related Protein
acetylcholine transmembrane transporter activity
dopamine transmembrane transporter activitySLC22A3;SLC22A1;SLC6A3;SLC22A2
identical protein bindingAXIN1;CCT7;RCAN1;DYNLT1C;ATL2;MTPAP;THG1L;KCNJ10;DYNLT1B
monoamine transmembrane transporter activitySLC18A1;SLC22A1;SLC6A3;SLC29A4;SLC6A4;SLC6A2;SLC18A2
norepinephrine transmembrane transporter activitySLC6A2;SLC22A1
organic cation transmembrane transporter activitySLC22A3;SLC7A8;SLC22A14;SLC22A2;SLC22A1
protein homodimerization activityZFP365;GABRR1;CCBL2;ANO6;PRDX4;UGT1A1;NRF1;FLT3;SQSTM1
quaternary ammonium group transmembrane transporter activitySLC22A5;SLC22A3;SLC22A1;SLC22A2
secondary active organic cation transmembrane transporter activity
transmembrane transporter activityATP5B;ATP5C1;SV2A;SLC22A20;ATP5J;ATP5F1;SV2BA;SLC17A9B;SLCO1D1
transporter activitySLCO2B1;RBP7B;SLCO4C1;SLC51B;LCN2;SYP;CSN2;FLVCR1;AQP10A

SLC22A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC22A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC22A1.

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