Background
This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Two alternatively spliced transcript variants encoding the same protein have been described.
Synonyms
SLC22A18; solute carrier family 22 (organic cation transporter), member 18; solute carrier family 22 member 18; ORCTL-2; organic cationic transporter-like 2; organic cation transporter-like protein 2; tumor suppressing subtransferable candidate 5; multi-membrane spanning polyspecific transporter; multi-membrane-spanning polyspecific transporter; imprinted multi-membrane spanning polyspecific transporter-related protein 1; imprinted multi-membrane-spanning polyspecific transporter-related protein 1; HET; ITM; BWR1A; Impt1; TSSC5; Orctl2; BWSCR1A; AW260131; Slc22a1l; p45-BWR1A