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SLC23A1

  • Official Full Name

    solute carrier family 23 (nucleobase transporters), member 1

  • Overview

    The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    SLC23A1; solute carrier family 23 (nucleobase transporters), member 1; SLC23A2, solute carrier family 23 (nucleobase transporters), member 2; solute carrier family 23 member 1; SVCT1; YSPL3; hSVCT1; Na(+)/L-ascorbic acid transporter 1; S23A1_HUMAN; Sodium-dependent vitamin C transporter 1; Yolk sac permease-like molecule 3; sodium-dependent vitamin C transporter-1; solute carrier family 23 (nucleobase transporters), member 2; SLC23A2;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SLC23A1-6802HF Recombinant Full Length Human SLC23A1 Protein, GST-tagged In Vitro Cell Free System GST 259 amino acids
Human SLC23A1-655H Recombinant Human SLC23A1 Protein, GST-tagged Wheat Germ GST 1-259 aa
Mouse SLC23A1-15285M Recombinant Mouse SLC23A1 Protein Mammalian Cell His
Mouse SLC23A1-8265M-B Recombinant Mouse SLC23A1 Protein Pre-coupled Magnetic Beads HEK293
Mouse SLC23A1-8265M Recombinant Mouse SLC23A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SLC23A1-5463R Recombinant Rat SLC23A1 Protein Mammalian Cell His
Rat SLC23A1-5122R Recombinant Rat SLC23A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SLC23A1-5122R-B Recombinant Rat SLC23A1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SLC23A1-4238R Recombinant Rhesus monkey SLC23A1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SLC23A1-4054R-B Recombinant Rhesus Macaque SLC23A1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SLC23A1-4054R Recombinant Rhesus Macaque SLC23A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish SLC23A1-7705Z Recombinant Zebrafish SLC23A1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SLC23A1 Related Articles

SLC23A1 involved in several pathways and played different roles in them. We selected most pathways SLC23A1 participated on our site, such as Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC23A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Vitamin digestion and absorptionSLC19A2;LRAT;FOLH1;MMACHC;SLC52A3;SCARB1;LMBRD1;BTD;GIF

SLC23A1 has several biochemical functions, for example, L-ascorbate:sodium symporter activity, L-ascorbic acid transporter activity, dehydroascorbic acid transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC23A1 itself. We selected most functions SLC23A1 had, and list some proteins which have the same functions with SLC23A1. You can find most of the proteins on our site.

Function Related Protein
L-ascorbate:sodium symporter activitySLC23A2;SLC23A1
L-ascorbic acid transporter activitySLC23A2;SLC23A1
dehydroascorbic acid transporter activitySLC2A1;SLC23A1;SLC2A2
sodium ion transmembrane transporter activityCNNM4;SLC23A1;ASIC4;SLC12A10.2;SLC12A10.1;SLC12A1;SLC12A10.3;TRAPPC10;SLC12A3
sodium-dependent L-ascorbate transmembrane transporter activitySLC23A2;SLC23A1
symporter activitySLC16A3;SLC6A4A;SLC6A19A;SLC34A2;SLC25A3;SLC1A2B;SLC1A3A;SLC10A5;SLC23A2
transporter activityATP6V0B;SLC37A4A;TMEM184BA;PMP2;CRABP1B;RBP1;SLC4A2A;SLC13A4;SLC13A1

SLC23A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC23A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC23A1.

Wade, KH; Forouhi, NG; et al. Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid. AMERICAN JOURNAL OF CLINICAL NUTRITION 101:202-209(2015).
Senthilkumari, S; Talwar, B; et al. Polymorphisms in sodium-dependent vitamin C transporter genes and plasma, aqueous humor and lens nucleus ascorbate concentrations in an ascorbate depleted setting. EXPERIMENTAL EYE RESEARCH 124:24-30(2014).
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