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SLC26A5

  • Official Full Name

    solute carrier family 26, member 5 (prestin)

  • Overview

    This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    SLC26A5; solute carrier family 26, member 5 (prestin); PRES, prestin (motor protein); prestin; deafness; neurosensory; autosomal recessive; 61; DFNB61; Deafness neurosensory autosomal recessive 61; DFNB 61; MGC118886; MGC118887; MGC118888; MGC118889; PRES; Prestin (motor protein); S26A5_HUMAN; Solute carrier family 26 member 5 (prestin); Solute carrier family 26 member 5; OTTHUMP00000195085; OTTHUMP00000195086; OTTHUMP00000195087; OTTHUMP00000195088; OTTHUMP00000195089; OTTHUMP00000195090; OTTHUMP00000195091; OTTHUMP00000195092; OTTHUMP00000211775; OTTHUMP00000211776;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Pig
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SLC26A5-112H Recombinant Human SLC26A5, GST-tagged Wheat Germ GST
Human SLC26A5-1520H Recombinant Human SLC26A5 Protein, His-tagged Yeast His
Mouse SLC26A5-15343M Recombinant Mouse SLC26A5 Protein Mammalian Cell His
Mouse SLC26A5-8302M-B Recombinant Mouse SLC26A5 Protein Pre-coupled Magnetic Beads HEK293
Mouse SLC26A5-8302M Recombinant Mouse SLC26A5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SLC26A5-5486R Recombinant Rat SLC26A5 Protein Mammalian Cell His
Rat SLC26A5-5145R Recombinant Rat SLC26A5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SLC26A5-5145R-B Recombinant Rat SLC26A5 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish SLC26A5-11519Z Recombinant Zebrafish SLC26A5 Mammalian Cell His
Pig SLC26A5-1190P Recombinant Pig SLC26A5 Protein, His-tagged E.coli N-His Ala524-Ser712
Chicken SLC26A5-3517C Recombinant Chicken SLC26A5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SLC26A5 Related Articles

SLC26A5 involved in several pathways and played different roles in them. We selected most pathways SLC26A5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC26A5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

SLC26A5 has several biochemical functions, for example, anion:anion antiporter activity, bicarbonate transmembrane transporter activity, chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC26A5 itself. We selected most functions SLC26A5 had, and list some proteins which have the same functions with SLC26A5. You can find most of the proteins on our site.

Function Related Protein
anion:anion antiporter activitySLC26A1;SLC4A1B;SLC26A9;SLC4A2B;SLC26A11;SLC4A8;SLC4A11;SLC26A3;SLC4A2A
bicarbonate transmembrane transporter activitySLC26A1;SLC4A1;SLC26A7;SLC26A3.2;CFTR;SLC26A9;SLC26A2;SLC26A4;SLC4A1B
chloride channel activityCLCN5;APOL1;FXYD3;SLC26A3;ANO2;SLC26A2;SLC26A6L;SLC26A11;CLIC6
oxalate transmembrane transporter activitySLC26A3.1;SLC26A7;SLC26A6;SLC26A5;SLC26A2;SLC26A1;SLC26A3;SLC26A11;SLC26A3.2
protein homodimerization activityVEGFB;S100A16;FGFR1OP2;RASGRP1;DCK;MAP3K13;PLEKHB1;TNNC1;GSTZ1
secondary active sulfate transmembrane transporter activitySLC26A3;SLC26A3.2;SLC26A9;SLC13A1;SLC26A7;SLC26A5;SLC26A6L;SLC26A3.1;SLC26A4
spectrin bindingSTX4A;ADD2;GNB1;CAMSAP1L1;DYNC1I1;ADD1;PTPRN;EPB49;MYO7A
sulfate transmembrane transporter activitySLC26A6L;SLC26A7;SLC26A6;SLC26A4;SLC26A1;SLC26A3.2;SLC26A9;SLC26A5;SLC26A11
transcription factor bindingNAB2;TBX5;KAT2A;POU5F1;NKX2-1;TRAPPC2;ARHGEF2;INSIG2;ZFPM1

SLC26A5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC26A5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC26A5.

Song, L; Santos-Sacchi, J; et al. An Electrical Inspection of the Subsurface Cisternae of the Outer Hair Cell. BIOPHYSICAL JOURNAL 108:568-577(2015).
Liu, HZ; Pecka, JL; et al. Characterization of Transcriptomes of Cochlear Inner and Outer Hair Cells. JOURNAL OF NEUROSCIENCE 34:11085-11095(2014).
  • Q&As
  • Reviews

Q&As (5)

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How prevalent are SLC26A5 mutations in individuals with hearing loss? 07/04/2022

SLC26A5 mutations are relatively rare compared to other genetic causes of hearing loss, but they are implicated in certain cases of hereditary hearing impairment.

Are there any SLC26A5-based treatments currently approved for clinical use? 02/15/2020

As of now, there are no SLC26A5-specific treatments approved for widespread clinical use, but research continues in this field.

How might advancements in SLC26A5 research impact future hearing loss treatments? 12/11/2019

Progress in understanding SLC26A5 could pave the way for innovative treatments that specifically target the underlying causes of certain types of hearing loss.

Can SLC26A5-targeted therapies potentially restore hearing function completely? 08/29/2018

The effectiveness of SLC26A5-targeted therapies in fully restoring hearing largely depends on the nature and extent of the mutation and its impact on outer hair cell function.

How is SLC26A5 relevant in the context of age-related hearing loss? 05/21/2016

While primarily associated with genetic hearing loss, understanding SLC26A5 function could provide insights into age-related hearing decline and potential interventions.

Customer Reviews (3)

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Reviews
11/26/2020

    This collaborative partnership greatly contributes to the success of my research projects and facilitates meaningful contributions to the scientific community.

    09/08/2019

      The manufacturer's support and expertise further enhance the utility of SLC26A5 in my experimental work, ensuring reliable and high-quality results.

      06/16/2019

        Another advantage of using SLC26A5 protein in trials is its potential as a therapeutic agent.

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