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SLC33A1

  • Official Full Name

    solute carrier family 33 (acetyl-CoA transporter), member 1

  • Overview

    The protein encoded by this gene is required for the formation of O-acetylated (Ac) gangliosides. The encoded protein is predicted to contain 6 to 10 transmembrane domains, and a leucine zipper motif in transmembrane domain III. Defects in this gene have been reported to cause spastic paraplegia autosomal dominant type 42 (SPG42) in one Chinese family, but not in similar patients of European descent. Two transcript variants encoding the same protein have been found for this gene.
  • Synonyms

    SLC33A1; solute carrier family 33 (acetyl-CoA transporter), member 1; ACATN, acetyl Coenzyme A transporter , spastic paraplegia 42 (autosomal dominant) , SPG42; acetyl-coenzyme A transporter 1; AT 1; AT1; ACATN; Acetyl CoA transporter; Acetyl Coenzyme A transporter; Acetyl coenzyme A transporter 1; Human Angiotensin II Type 1 Receptor; Solute carrier family 33 (acetyl CoA transporter) member 1; Solute carrier family 33 member 1; spastic paraplegia 42 (autosomal dominant); SPG42; OTTHUMP00000212981; OTTHUMP00000212982; OTTHUMP00000212983; AT-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • 8His
  • MBP,Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SLC33A1-3052H Recombinant Human SLC33A1, His-tagged E.Coli or Yeast His 549
Human SLC33A1-4321H Recombinant Human SLC33A1 protein, GST-tagged Wheat Germ GST
Human SLC33A1-1629HCL Recombinant Human SLC33A1 cell lysate N/A
Human SLC33A1-6690H Recombinant Human SLC33A1 Protein (Met1-Ser74), N-His tagged E.coli N-His Met1-Ser74
Human SLC33A1-0854H Recombinant Human SLC33A1 Protein (S2-N549), 8×His-MBP, Flag tagged Insect Cell 8His-MBP,Flag S2-N549
Human SLC33A1-301153H Recombinant Human SLC33A1 protein, GST-tagged E.coli GST Met1-Ser73
Human SLC33A1-703HF Recombinant Full Length Human SLC33A1 Protein, GST-tagged In Vitro Cell Free System GST 549 amino acids
Mouse SLC33A1-15384M Recombinant Mouse SLC33A1 Protein Mammalian Cell His
Mouse SLC33A1-8327M Recombinant Mouse SLC33A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SLC33A1-8327M-B Recombinant Mouse SLC33A1 Protein Pre-coupled Magnetic Beads HEK293
Rat SLC33A1-5509R Recombinant Rat SLC33A1 Protein Mammalian Cell His
Rat SLC33A1-5168R Recombinant Rat SLC33A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SLC33A1-5168R-B Recombinant Rat SLC33A1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish SLC33A1-11330Z Recombinant Zebrafish SLC33A1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SLC33A1 Related Articles

SLC33A1 involved in several pathways and played different roles in them. We selected most pathways SLC33A1 participated on our site, such as Glycosphingolipid biosynthesis - ganglio series, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC33A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycosphingolipid biosynthesis - ganglio seriesST6GALNAC4;B4GALNT1;ST8SIA1;ST8SIA5;GLB1;ST3GAL2;HEXB;ST6GALNAC6;HEXA
Metabolic pathwaysMGAT3;CHIA.4;GLULB;AKR1B1L;GPI;ACOT8;PLCD1;PLA2G4A;CYP3A41B

SLC33A1 has several biochemical functions, for example, acetyl-CoA transporter activity, solute:proton symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC33A1 itself. We selected most functions SLC33A1 had, and list some proteins which have the same functions with SLC33A1. You can find most of the proteins on our site.

Function Related Protein
acetyl-CoA transporter activity
solute:proton symporter activityMFSD3;SLC33A1;SLC11A2

SLC33A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC33A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC33A1.

METTL8; MSL1; HAX1; CLIC1; SLC27A2; PHGDH; ZW10; SNUPN; MT-ATP6; MT-ATP8; PFN1; HSP90AB1; HSP90B1; ATP2A2; ATP5A1; EEF1G; CANX; EEF1D; SLC7A1; MAT2A

Mao, F; Li, ZH; et al. Identification and Functional Analysis of a SLC33A1: c.339T > G (p.Ser113Arg) Variant in the Original SPG42 Family. HUMAN MUTATION 36:240-249(2015).
Peng, YJ; Li, M; et al. Deficient Import of Acetyl-CoA into the ER Lumen Causes Neurodegeneration and Propensity to Infections, Inflammation, and Cancer. JOURNAL OF NEUROSCIENCE 34:6772-6789(2014).
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