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SLC5A8

Official Full Name

solute carrier family 5 (iodide transporter), member 8
Overview

SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 (PubMed 12107270)) and;monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 (PubMed 15322102)). In;kidney, SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in reabsorption of lactate and;maintenance of blood lactate levels (Thangaraju et al., 2006 (PubMed 16873376)).
Synonyms

SLC5A8; solute carrier family 5 (iodide transporter), member 8; sodium-coupled monocarboxylate transporter 1; AIT; Apical iodide transporter; Electrogenic sodium monocarboxylate cotransporter; MGC125354; SC5A8_HUMAN; SMCT; SMCT1; sodium coupled monocarboxylate transporter 1; Sodium iodide related cotransporter; Sodium iodide-related cotransporter; solute carrier family 5 iodide transporter member 8; Solute carrier family 5 member 8;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Mouse	SLC5A8-15489M	Recombinant Mouse SLC5A8 Protein	Mammalian Cell	His	Inquiry
Mouse	SLC5A8-8401M-B	Recombinant Mouse SLC5A8 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	SLC5A8-8401M	Recombinant Mouse SLC5A8 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry

Involved Pathway
Protein Function
Interacting Protein
SLC5A8 Related Articles

SLC5A8 involved in several pathways and played different roles in them. We selected most pathways SLC5A8 participated on our site, such as Organic anion transporters, SLC-mediated transmembrane transport, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC5A8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Organic anion transporters	SLC17A7A;SLC5A8;SLC25A10;SLC17A1
SLC-mediated transmembrane transport	SLC20A1B;SLC26A1;SLC4A3;SLC38A3A;SLC35B4;SLC29A3;SLC5A4;SLC26A2;SLC24A4A
Transmembrane transport of small molecules	CLCN7;MAGT1;SLC26A6L;SLC17A7A;SLC2A6;CTNS;SLC31A1;HTR3C;SLC14A1
Transport of inorganic cations/anions and amino acids/oligopeptides	SLC4A8;SLC6A19A;SLC12A5B;SLC43A2A;SLC12A4;SLC6A6;SLC15A1B;SLC7A11;SLC34A3

SLC5A8 has several biochemical functions, for example, symporter activity, transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC5A8 itself. We selected most functions SLC5A8 had, and list some proteins which have the same functions with SLC5A8. You can find most of the proteins on our site.

Function	Related Protein
symporter activity	SLC16A14;SLC16A6;PPP1R42;SLC16A12;SLC38A3;SLC17A4;SLC1A7A;SLC6A2;SLC15A5
transporter activity	TMEM184C;VPS9D1;NUP98;SLC4A4A;PTGDSB;ABCA1B;SLC22A23;STEAP2;ABCA6

SLC5A8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC5A8 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC5A8.

Helm, J; Coppola, D; et al. SLC5A8 Nuclear Translocation and Loss of Expression are Associated With Poor Outcome in Pancreatic Ductal Adenocarcinoma. PANCREAS 41:904-909(2012).

Gopal, E; Umapathy, NS; et al. Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1768:2690-2697(2007).

Gopal, E; Miyauchi, S; et al. Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 292:G402-G408(2007).