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SLC6A1

  • Official Full Name

    solute carrier family 6 (neurotransmitter transporter), member 1

  • Overview

    The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009]
  • Synonyms

    SLC6A1; solute carrier family 6 (neurotransmitter transporter), member 1; GAT1; GABATR; GABATHG; sodium- and chloride-dependent GABA transporter 1; GAT-1; GABA transporter 1; solute carrier family 6 member 1; solute carrier family 6 (neurotransmitter transporter, GABA), member 1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SLC6A1-3326H Recombinant Human SLC6A1 protein, His-tagged E.coli His 1-52 aa
Human SLC6A1-1796H Recombinant Human SLC6A1 protein, GST-tagged E.coli GST 1-52 aa
Mouse SLC6A1-15491M Recombinant Mouse SLC6A1 Protein Mammalian Cell His
Mouse SLC6A1-8403M-B Recombinant Mouse SLC6A1 Protein Pre-coupled Magnetic Beads HEK293
Mouse SLC6A1-8403M Recombinant Mouse SLC6A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SLC6A1-5561R Recombinant Rat SLC6A1 Protein Mammalian Cell His
Rat SLC6A1-5220R Recombinant Rat SLC6A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SLC6A1-5220R-B Recombinant Rat SLC6A1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SLC6A1-4301R Recombinant Rhesus monkey SLC6A1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SLC6A1-4117R-B Recombinant Rhesus Macaque SLC6A1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SLC6A1-4117R Recombinant Rhesus Macaque SLC6A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SLC6A1 Related Articles
  • SLC6A1 Related Research Area

SLC6A1 involved in several pathways and played different roles in them. We selected most pathways SLC6A1 participated on our site, such as GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC6A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
GABAergic synapseNSF;SLC38A1;SLC6A13;GNAI1;SLC38A2;GABBR2;SLC12A5;GLUL;GNB3

SLC6A1 has several biochemical functions, for example, gamma-aminobutyric acid:sodium symporter activity, neurotransmitter:sodium symporter activity, symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC6A1 itself. We selected most functions SLC6A1 had, and list some proteins which have the same functions with SLC6A1. You can find most of the proteins on our site.

Function Related Protein
gamma-aminobutyric acid:sodium symporter activitySLC6A11A;SLC6A12;SLC6A1;SLC6A13L;SLC6A11;SLC6A1B;SLC6A1A;SLC6A13
neurotransmitter:sodium symporter activitySLC6A12;SLC6A5;SLC6A4B;SLC6A19A;SLC6A8;SLC6A15;SLC6A1B;SLC6A6B;SLC6A1
symporter activitySLC6A4A;SLC6A4B;SLC17A6B;SLC1A7B;SLC17A5;SLC36A4;SLC6A11;SLC6A1B;SLC16A9

SLC6A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC6A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC6A1.

Dikow, N; Maas, B; et al. 3p25.3 Microdeletion of GABA Transporters SLC6A1 and SLC6A11 Results in Intellectual Disability, Epilepsy and Stereotypic Behavior. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164A:3061-3068(2014).
Tritsch, NX; Oh, WJ; et al. Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis. ELIFE 3:-(2014).
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