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SLC6A12

  • Official Full Name

    solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12

  • Overview

    SLC6A12, also known as BGT-1, is a member of the Na+ - and Cl- -dependent neurotransmitter transporter family. It transports both betaine and the neurotransmitter GABA at the blood-brain barrier as well as controls osmoregulation. This betaine/GABA transp
  • Synonyms

    SLC6A12; solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12; sodium- and chloride-dependent betaine transporter; BGT 1; gamma-aminobutyric acid transporter; Na(+)/Cl(-) betaine/GABA transporter; BGT1; GAT2; BGT-1; FLJ38727;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SLC6A12-2781H Recombinant Human SLC6A12, His-tagged E.coli His 548-614aa
Rat SLC6A12-5563R Recombinant Rat SLC6A12 Protein Mammalian Cell His
Rat SLC6A12-5222R Recombinant Rat SLC6A12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SLC6A12-5222R-B Recombinant Rat SLC6A12 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SLC6A12-4303R Recombinant Rhesus monkey SLC6A12 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SLC6A12-4119R Recombinant Rhesus Macaque SLC6A12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SLC6A12-4119R-B Recombinant Rhesus Macaque SLC6A12 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SLC6A12 Related Articles

SLC6A12 involved in several pathways and played different roles in them. We selected most pathways SLC6A12 participated on our site, such as Amino acid transport across the plasma membrane, Creatine metabolism, GABA synthesis, release, reuptake and degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC6A12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Amino acid transport across the plasma membraneSLC3A2B;SLC38A5B;SLC43A1B;SLC7A11;SLC38A4;SLC6A6A;SLC6A12;SLC6A19A;SLC7A8A
Creatine metabolismCKM;SLC6A8;SLC6A7;SLC6A12;CKMB;LSM1;CKMT2;CKMT2A;CKMT1B
GABA synthesis, release, reuptake and degradationSLC6A1A;RAB3AB;CCDC167;SLC6A1B;SNAP25A;CPLX2L;ABAT;SNAP25B;SLC6A12
MetabolismCPNE3;B3GNT3;FA2H;ACOT2;NAT2;BPNT1;COQ6;NUDT1;SPTLC1
Metabolism of amino acids and derivativesDAO;AZIN1A;AMD2;SAT1B;AHCY;HIBADHA;LSM1;SLC25A15;PCBD1
Metabolism of polyaminesCKBA;CKMT2;SLC25A2;SAT1B;CKMT1B;CKMT2A;PAOX;AZIN1;NQO1
Na+/Cl- dependent neurotransmitter transportersSLC6A11;SLC6A18;SLC6A9;SLC6A7;SLC6A19A;SLC6A5;SLC6A1A;SLC6A20B;SLC6A20A
Neuronal SystemKCNN4;KCNA5;KCNQ2A;ARL6IP5;CCDC167;KCNN2;CACNB4B;AKAP5;DDX1

SLC6A12 has several biochemical functions, for example, gamma-aminobutyric acid:sodium symporter activity, neurotransmitter:sodium symporter activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC6A12 itself. We selected most functions SLC6A12 had, and list some proteins which have the same functions with SLC6A12. You can find most of the proteins on our site.

Function Related Protein
gamma-aminobutyric acid:sodium symporter activitySLC6A12;SLC6A13;SLC6A11A;SLC6A1;SLC6A13L;SLC6A1B;SLC6A11;SLC6A1A
neurotransmitter:sodium symporter activitySLC6A5;SLC6A6B;SLC6A1A;SLC6A13L;SLC6A20A;SLC6A19B;SLC6A16B;SLC6A2;SLC6A4A
protein bindingSRGAP3;SFMBT1;PAK6;SEMA3E;CD2;ACVR1L;STAT5B;SDCBP2;ISG20L2

SLC6A12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC6A12 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC6A12.

REL; SCRIB

Holmseth, S; Zhou, Y; et al. Specificity Controls for Immunocytochemistry: The Antigen Preadsorption Test Can Lead to Inaccurate Assessment of Antibody Specificity. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 60:174-187(2012).
Zhou, Y; Holmseth, S; et al. The betaine-GABA transporter (BGT1, slc6a12) is predominantly expressed in the liver and at lower levels in the kidneys and at the brain surface. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 302:F316-F328(2012).
Zhou, Y; Holmseth, S; et al. EVIDENCE AGAINST A ROLE OF THE BETAINE-GABA TRANSPORTER (BGT1, SLC6A12) IN THE CONTROL OF GABA RECEPTOR ACTIVATION. GLIA 59:S69-S70(2011).
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