SLC9A3R1
-
Official Full Name
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
-
Overview
This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.[provided by RefSeq, Sep 2009] -
Synonyms
SLC9A3R1; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1; EBP50; NHERF; NHERF1; NHERF-1; NPHLOP2; Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Na+/H+ exchange regulatory co-factor; regulatory cofactor of Na(+)/H(+) exchanger; ezrin-radixin-moesin binding phosphoprotein-50; ezrin-radixin-moesin-binding phosphoprotein 50; solute carrier family 9 isoform A3 regulatory factor 1; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- C
- Myc
- DDK
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- SLC9A3R1 Related Articles
SLC9A3R1 involved in several pathways and played different roles in them. We selected most pathways SLC9A3R1 participated on our site, such as PDGFR-beta signaling pathway, Thromboxane A2 receptor signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC9A3R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PDGFR-beta signaling pathway | SLC9A3R1;GRB10;SLA;SNX15;DOK1 |
| Thromboxane A2 receptor signaling | SLC9A3R1;ADRBK2;ARR3 |
SLC9A3R1 has several biochemical functions, for example, PDZ domain binding, beta-2 adrenergic receptor binding, beta-catenin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC9A3R1 itself. We selected most functions SLC9A3R1 had, and list some proteins which have the same functions with SLC9A3R1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| PDZ domain binding | GNG5;GJA1;CCDC88C;PTENA;PLEKHA2;BAIAP2;CXXC4;DLG4;USHBP1 |
| beta-2 adrenergic receptor binding | NEDD4;SLC9A3R1;GNAS;BDKRB2;PDE4D |
| beta-catenin binding | DVL3;CHD8;KDM6B;TBL1XR1;BCL9L;CTNNA1;DACT3;AXIN2;TCF7L1B |
| chloride channel regulator activity | SGK2A;SGK1;SGK2;SGK2B;SLC9A3R1;BSND;CHRNA7;SGK3 |
| dopamine receptor binding | CLIC6;SLC9A3R1 |
| growth factor receptor binding | FYN;SLC9A3R1;APP;SRC |
| phosphatase binding | SH3YL1;MAPK3;PPP1R35;PPP1R18;CTSC;SMAD2;SLC9A3R1;SPRED1;PPP1R37 |
| protein binding | SPSB4;CD200R2;WWC1;FAM90A1;NCDN;CD63;RACGAP1;AGR2;FBXW11 |
| protein complex binding | FLCN;CDK5RAP1;SREBF1;CASP8;NDUFA9;NDUFA4;HCLS1;CD2AP;TAB1 |
| protein complex scaffold | TELO2;PKP2;GNB2L1;SLC9A3R2;HOMER1;ITSN1;CAV2;MAGI1;MPP7 |
| protein self-association | AGA;MALT1;CTSC;CCDC88C;CCL5;RSAD2;ACHE;AXIN1;ABCD3 |
| receptor binding | DAO1;FGF12A;F2RL1;DHRS4;FGF13A;ACOX1;HLA-E;LAMA4;GNB2L1 |
SLC9A3R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC9A3R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC9A3R1.
CFTR; PDGFRB; PTEN; MSN
- Q&As
- Reviews
Q&As (5)
Ask a questionSLC9A3R1 consists of two tandem PDZ structural domains and a C-terminal ERM-binding structural domain.
SLC9A3R1 is closely related to breast cancer research and is expected to be a candidate breast cancer inhibitory protein.
SLC9A3R1 is able to form protein complexes with EGFR and NF2 at intercellular adhesion junctions, thereby preventing EGFR internalization and signaling.
Overexpression of SLC9A3R1 inhibits tumor cell proliferation.
SLC9A3R1 binds to PDGFR and attenuates PDGFR signaling.
Customer Reviews (3)
Write a reviewProtein products are put into experiments with good effect and reliable experimental results.
The technician modified my experimental protocol so that my experiment went smoothly.
The high quality of the purchased protein helped me to obtain satisfactory experimental results.
Ask a Question for All SLC9A3R1 Products
Required fields are marked with *
My Review for All SLC9A3R1 Products
Required fields are marked with *
