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SLX1B

Official Full Name

SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
Overview

This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) gene.
Synonyms

SLX1B; SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae); GIY YIG domain containing 2 , GIYD2; structure-specific endonuclease subunit SLX1; MGC5178; FLJ23439; GIY YIG domain containing 2; GIYD 2; MGC2532; GIY-YIG domain-containing protein 1; GIYD1; GIYD2; SLX1A;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Rat
Rhesus Macaque

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SLX1B-5924HCL	Recombinant Human GIYD2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	SLX1B-4920H	Recombinant Human SLX1B Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	SLX1B-5289HF	Recombinant Full Length Human SLX1B Protein, GST-tagged	In Vitro Cell Free System	GST	275 amino acids	Inquiry
Rat	SLX1B-5606R	Recombinant Rat SLX1B Protein	Mammalian Cell	His		Inquiry
Rat	SLX1B-5265R	Recombinant Rat SLX1B Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	SLX1B-5265R-B	Recombinant Rat SLX1B Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	SLX1B-4328R	Recombinant Rhesus monkey SLX1B Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	SLX1B-4144R	Recombinant Rhesus Macaque SLX1B Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	SLX1B-4144R-B	Recombinant Rhesus Macaque SLX1B Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

SLX1B involved in several pathways and played different roles in them. We selected most pathways SLX1B participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLX1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Fanconi anemia pathway	WDR48;FANCI;FANCL;FANCD2;PMS2;BRIP1;HES1;BRCA2;FANCA

SLX1B has several biochemical functions, for example, 5-flap endonuclease activity, crossover junction endodeoxyribonuclease activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLX1B itself. We selected most functions SLX1B had, and list some proteins which have the same functions with SLX1B. You can find most of the proteins on our site.

Function	Related Protein
5-flap endonuclease activity	SLX1B;FEN1;FAN1;DNA2
crossover junction endodeoxyribonuclease activity	GEN1;SLX1B
metal ion binding	S100A10A;CLCA2;ZNF529;ZNF554;POLD1;ATP11A;CYP2AD6;SP4;FLYWCH1
protein binding	APOOL;GOLGA3;AIG1;RPH3A;PLK1S1;PTPRB;HIST1H2AL;ACTN3;ZFAND2B

SLX1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLX1B here. Most of them are supplied by our site. Hope this information will be useful for your research of SLX1B.

SLX4; ERCC4; MUS81; GRB2; TUBA1B; ribF; q7ckh1_yerpe; sspA; q81zc1_bacan