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SLX4

Official Full Name

SLX4 structure-specific endonuclease subunit
Overview

This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.[provided by RefSeq, Jan 2011]
Synonyms

SLX4; SLX4 structure-specific endonuclease subunit; FANCP; BTBD12; MUS312; structure-specific endonuclease subunit SLX4; BTB (POZ) domain containing 12; BTB/POZ domain-containing protein 12; SLX4 structure-specific endonuclease subunit homolog;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	SLX4-188HCL	Recombinant Human SLX4 cell lysate		N/A	Inquiry
Mouse	SLX4-15581M	Recombinant Mouse SLX4 Protein	Mammalian Cell	His	Inquiry
Mouse	SLX4-8455M	Recombinant Mouse SLX4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	SLX4-8455M-B	Recombinant Mouse SLX4 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SLX4 Related Articles

SLX4 involved in several pathways and played different roles in them. We selected most pathways SLX4 participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Fanconi anemia pathway	FAN1;TOP3B;EME1;MUS81;REV1;BLM;C19orf40;FANCA;EME2

SLX4 has several biochemical functions, for example, contributes_to 3-flap endonuclease activity, contributes_to 5-flap endonuclease activity, contributes_to crossover junction endodeoxyribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLX4 itself. We selected most functions SLX4 had, and list some proteins which have the same functions with SLX4. You can find most of the proteins on our site.

Function	Related Protein
contributes_to 3-flap endonuclease activity
contributes_to 5-flap endonuclease activity
contributes_to crossover junction endodeoxyribonuclease activity	SLX4;RAD51C;XRCC3
enzyme activator activity	RICTOR;PRKCE;CXCL1;SEC14L2;MMP17;DNMT3L;RAB3GAP2;CASP9;GMFG
protein binding	CSE1L;ACTN2;HIST1H3F;CAST;S100A13;HIST1H2AG;RELL2;ECT2;SYT7

SLX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLX4.

ERCC4; PLK1; SLX1A

Guervilly, JH; Takedachi, A; et al. The SLX4 Complex Is a SUMO E3 Ligase that Impacts on Replication Stress Outcome and Genome Stability. MOLECULAR CELL 57:123-137(2015).

Sarbajna, S; Davies, D; et al. Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe. GENES & DEVELOPMENT 28:1124-1136(2014).