SMAD4
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Official Full Name
SMAD family member 4
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Overview
SMAD4 is a member of the Mothers Against Dpp (MAD)-related family of proteins. SMAD4 is functionally distinct among the SMAD family, and is required for the assembly and transcriptional activation of diverse, SMAD-DNA complexes. SMAD4 appears to be not regulated by phosphorylation, but acts as a common mediator of TGF-beta, activin, and bone morphogenetic protein signaling responses. SMAD4 is frequently inactivated in pancreatic, biliary and colorectal tumors. -
Synonyms
SMAD4; SMAD family member 4; MAD, mothers against decapentaplegic homolog 4 (Drosophila) , MADH4, SMAD, mothers against DPP homolog 4 (Drosophila); mothers against decapentaplegic homolog 4; DPC4; MAD homolog 4; SMAD, mothers against DPP homolog 4; deleted in pancreatic carcinoma locus 4; deletion target in pancreatic carcinoma 4; mothers against decapentaplegic, Drosophila, homolog of, 4; JIP; MADH4; MYHRS;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- SMAD4 Related Gene Family
- SMAD4 Related Research Area
- SMAD4 Related Signal Pathway
SMAD4 involved in several pathways and played different roles in them. We selected most pathways SMAD4 participated on our site, such as FoxO signaling pathway, Cell cycle, Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FoxO signaling pathway | MAP2K2B;PRKAG1;BNIP4;CDKN2D;CCND2A;RBL2;PIK3R3;STAT3;TGFBR1 |
| Cell cycle | TUBGCP4;CDC14A;CCND2;MAPRE1A;YWHAB;NINL;CDK6;SMAD2;RAD21A |
| Wnt signaling pathway | CAMK2D;MAPK9;RAC2;FZD7B;WNT6;DAAM2;WNT11B;MMP7;WNT7AA |
| TGF-beta signaling pathway | ACVR1L;ROCK1;LTBP1;SMAD2;CHD;BMPR1B;ID1;BMPR2A;INHBB |
| Hippo signaling pathway | FZD3;SMAD2;GDF5;PARD6B;WNT6;FRMD6;TEAD3;WNT3;PRKCI |
| Adherens junction | AASS;SMAD3A;FYNB;SSX2IPA;RHOAD;PVRL3B;ACTN2B;FGFR1;NLK1 |
| Signaling pathways regulating pluripotency of stem cells | INHBA;FGFR3;WNT8A;INHBC;WNT1;HESX1;HAND1;FZD2;PCGF6 |
| Hepatitis B | MAP2K2;MMP9;Fasl;STAT3;IKBKE;NFATC2;TP53;TBK1;STAT4 |
| HTLV-I infection | PCNA;VDAC2;VDAC1;XBP1;HLA-DMB;CALR;ANAPC1;RB1;NFATC2 |
| Pathways in cancer | BIRC3;LAMA5;RXRB;GNG5;PLD1;MMP1;GLI1;PIK3R2;PIK3CG |
| Colorectal cancer | RAF1;AXIN1;TGFB2;RAC1;TCF7;RHOA;TP53;PIK3CA;BAX |
| Pancreatic cancer | CCND1;TGFB2;RALGDS;SMAD4;PIK3R1;TP53;VEGFA;ARHGEF6;PIK3CB |
| Chronic myeloid leukemia | TRP53;PTPN11;RUNX1;KRAS;CRKL;CRK;PIK3CD;SMAD4;CTBP2 |
SMAD4 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD4 itself. We selected most functions SMAD4 had, and list some proteins which have the same functions with SMAD4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to DNA binding | CLOCKA;SMAD2;RFC3;SMAD4;MAFGA;GTF3C3;GTF3C5;GTF3C6;GTF3C4 |
| I-SMAD binding | CTNNB1;SMAD6;SMAD2;SMURF1;SMAD4;SMAD7;SMAD1;AXIN1;TGFBR1 |
| R-SMAD binding | FOS;CTNNB1;SMAD4;ZC3H3;C18orf1;PPM1A;SMAD3;JUN;ANKRD1 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | TCF7L2;KLF17;FIGLA;MYPOP;ESRRA;ETV2;TGIF1;GMEB2;RFX1 |
| RNA polymerase II transcription factor binding | MEF2A;T;ZFPM2;GATA6;ZGLP1;ZFPM1;GSK3B;KDM1A;TP53 |
| chromatin binding | HDAC7A;NSD1;KIAA0101;MED12;NKX6;CITED1;PAX3;MORF4L1;MBD1 |
| collagen binding | ITGA2;TLL1;USH2A;MMP9;SMAD3;ITGA3;CTSS;CD44;SMAD7 |
| core promoter proximal region sequence-specific DNA binding | DMRTC2;KLF4;DMRTC1C2;SMAD3;MIXL1;SP3;GATA3;TFAP2A;MEF2C |
| identical protein binding | ADORA2A;TLR3;SCAND1;LZTFL1;CRYAB;NQO1;DNM1L;PRKD1;PRMT8 |
| metal ion binding | GRIN2A;ACO1;SUV39H1A;SNAI1A;GPHN;ZHX2;PNLIP;ASH2L;ATP8B1 |
| protein binding | CLU;BCL11A;SCNN1D;CARD9;KLHL3;ATP6V1B2;FAM111A;FAM54A;PSMB10 |
| protein heterodimerization activity | RXRA;CHRAC1;HIST1H4C;UGT1A6A;DMRT3A;IKBKB;SCGB2A1;STX1A;MAFGB |
| protein homodimerization activity | BMPR1A;NR4A3;ERBB4;GREM2;CISD2;TERF1;APOA2;DPYD;MYH9 |
| contributes_to sequence-specific DNA binding | NEUROD1;FIGLA;PPARG;HDAC4;SMAD4;EPAS1;TRIM28;ARNT;TCF3 |
| transcription factor activity, RNA polymerase II transcription factor binding | NACC2;SMAD4;YAP1;ATF2;HIF1A;ZNF296;MAMSTR;SRF;THRAA |
| contributes_to transcription factor activity, protein binding | SMAD3;SMAD4 |
| contributes_to transcription factor activity, sequence-specific DNA binding | SMAD3;TAF12;SOX19B;TAF6;TAF7;FOXH1;RXRA;SOX1A;VDRB |
| transcription regulatory region DNA binding | TFEB;XBP1;DHX36;CTCF;AIRE;XRCC5;ZNF174;SALL1A;ATF4 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | NR4A2;CEBPG;TFE3;JUN;ETV2;MYBL2;FOXD1;NR2E1;NR4A1 |
| transforming growth factor beta receptor, common-partner cytoplasmic mediator activity |
SMAD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD4.
SMAD3; SMAD2
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