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SMARCA4

  • Official Full Name

    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

  • Overview

    The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
  • Synonyms

    SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; BRG1; SNF2; SWI2; MRD16; RTPS2; BAF190; SNF2L4; SNF2LB; hSNF2b; BAF190A; transcription activator BRG1; SNF2-beta; SNF2-like 4; protein BRG-1; nuclear protein GRB1; brahma protein-like 1; BRM/SWI2-related gene 1; homeotic gene regulator; protein brahma homolog 1; BRG1-associated factor 190A; sucrose nonfermenting-like 4; ATP-dependent helicase SMARCA4; mitotic growth and transcription activator; global transcription activator homologous sequence;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Insect Cell
  • Insect cells
  • Insect Cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • Yeast
  • C
  • His,C
  • Flag
  • FLAG
  • GST
  • His
  • His (Fc)
  • Avi
  • His|Flag
  • N/A
  • N
  • MBP
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SMARCA4-72H Active Recombinant Human SMARCA4, His&FLAG-tagged E.coli His/Flag
Human SMARCA4-1019H Active Recombinant Human SMARCA4 Sf9 Insect Cell N/A
Human SMARCA4-1910H Recombinant Human SMARCA4, GST-tagged E.coli GST 1448-1575 aa
Human SMARCA4-197H Recombinant Human SMARCA4 Protein, His-tagged E.coli His
Human SMARCA4-1915H Recombinant Human SMARCA4, His-tagged E.coli His 1480-1603
Human SMARCA4-27676TH Recombinant Human SMARCA4 N/A
Human SMARCA4-27675TH Recombinant Human SMARCA4, His-tagged Insect Cell His
Human SMARCA4-2804H Recombinant Human SMARCA4, GST-tagged E.coli GST 207-298aa
Human SMARCA4-198H Recombinant Human SMARCA4 Protein, His-tagged E.coli His 1148-1569
Human SMARCA4-1916H Recombinant Human SMARCA4, GST-tagged E.coli GST 1480-1603
Human SMARCA4-5521H Recombinant Human SMARCA4 protein, His-tagged Yeast His 700-1246aa
Human SMARCA4-21H Recombinant Human SMARCA4 protein(700-1246aa), MBP&His-Avi-tagged E.coli N-MBP&C-His-Avi 700-1246aa
Human SMARCA4-01HFL Recombinant Full Length Human SMARCA4 Protein, C-His,C-Flag-tagged Insect cells C-His,C-Flag
Human SMARCA4-01H Recombinant Human SMARCA4 Protein, FLAG-tagged Insect Cells FLAG
Human SMARCA4-05H Recombinant Human SMARCA4 Protein (658-1328), N-FLAG tagged Insect Cell N-FLAG 658-1328
Human SMARCA4-20H Recombinant Human SMARCA4 protein(700-1246aa), His-tagged E.coli N-His 700-1246aa
Human SMARCA4-22H Recombinant Human SMARCA4 protein(808-1092aa), His-tagged E.coli N-His 808-1092aa
Human SMARCA4-16H Recombinant Human SMARCA4 Protein (1448-1569), N-GST tagged E.coli N-GST 1448-1569
Mouse SMARCA4-15597M Recombinant Mouse SMARCA4 Protein Mammalian Cell His
Mouse SMARCA4-8461M Recombinant Mouse SMARCA4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SMARCA4-8461M-B Recombinant Mouse SMARCA4 Protein Pre-coupled Magnetic Beads HEK293
Rat SMARCA4-15R Recombinant Rat SMARCA4 Protein, His-tagged E.coli His 756-1347aa
Chicken SMARCA4-6616C Recombinant Chicken SMARCA4 Mammalian Cell His
Kit-1646 HEK 293 SMARCA4 Bromodomain Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SMARCA4 Related Research Area

SMARCA4 involved in several pathways and played different roles in them. We selected most pathways SMARCA4 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Direct p53 effectors, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMARCA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chromatin modifying enzymesMSL2;SMARCE1;EED;KDM4B;ING3;SMYD2A;KDM7AB;MORF4L1;SAP30L
Chromatin organizationYEATS4;USP22;SAP30L;KDM7AB;SMARCB1A;AEBP2;SMYD2;ING3;PHF2
Direct p53 effectorsDUSP5;PCBP4;EPHA2;GDF15;CCNK;GADD45A;ARID3A;BCL2L14;NDRG1
Formation of the beta-catenin:TCF transactivating complexH3F3B.1;LEO1;RBBP5;H3F3D;TLE2;TLE3B;BCL9L;PYGO1;BCL9
Glucocorticoid receptor regulatory networkSMARCD1;EGR1;BGLAP;SMARCA4;KRT5;NR1I3;KRT14;KRT17;POU2F1
Integrated Breast Cancer PathwayUSP15;AHR;CYP19A1;PLK3;BACH1;GRN;DHTKD1;UBE2F;RPP38
Prostate CancerSMARCD1;NDRG1;MAP2K1;FOXO1;HSP90B1;PTEN;INS2;TCF7L2;PDGFA
RMTs methylate histone argininesPBRM1;SMARCB1A;SMARCA2;SMARCD3;PRMT7;SMARCD1;SMARCD3B;PRMT5;ACTL6B

SMARCA4 has several biochemical functions, for example, ATP binding, DNA polymerase binding, DNA-dependent ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SMARCA4 itself. We selected most functions SMARCA4 had, and list some proteins which have the same functions with SMARCA4. You can find most of the proteins on our site.

Function Related Protein
ATP bindingABCB3L1;MYH7;ABCA9;SGK2;BLM;RPS6KB2;ACVR1C;HSPA8;AK8
DNA polymerase bindingHMGB1;FANCI;CDK2AP1;RAD51;ACD;LONP1;PCNA;SMARCA4;FANCD2
DNA-dependent ATPase activityCHD6;RAD51D;MSH3;MSH5;ERCC6;DDX11;RAD51B;DMC1;SMARCA2
RNA polymerase I CORE element sequence-specific DNA bindingSMARCB1;EFCAB11;PIH1D1;RRN3;BAZ2A;SMARCA4;TAF1B;TAF1C
contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA bindingCHD4;MBD3;HDAC2;GATAD2B;MTA2;ACTB;SMARCA4;SMARCC1;ACTL6A
contributes_to RNA polymerase II distal enhancer sequence-specific DNA bindingMTA2;CHD4;SMARCC1;RBBP4;SMARCA4;HDAC1;SMARCC2;MBD3;ACTL6A
RNA polymerase II transcription coactivator activityISL1;PSIP1;NEUROD1;PHF17;SOX4;SOX11;CITED2;TBX20;MYOCD
Tat protein bindingDLL1;SMARCA4;GABARAPL1;SMARCB1;ACTB;MDFIC;NPM1;TRIM32
androgen receptor bindingEP300;DAXX;NSD1;FOXP1;TRIM68;PARK7;NRIP1;DDX5;FHL2
helicase activitySETX;IFIH1;MOV10B.1;DDX58;MCM8;MOV10B.2;FANCM;HELLS;DHX34
lysine-acetylated histone bindingPSME4B;TRIM24;BRD9;CARM1;BRD3;BRDT;MLL1;SMARCA4;PHIP
contributes_to nucleosomal DNA bindingSMARCB1;HDAC2;SMARCE1;ACTL6A;RBBP4;SMARCA4;GATAD2B;SMARCC2;CHD4
p53 bindingSIRT1;CHD8;TP63;CDKN2AIP;CDKN2A;DAXX;TP53RK;ZMAT3;BCL2L12
protein N-terminus bindingRASSF1;SLA2;TSC1;TP53;TRP53;SUV39H1;PPP1CC;ERCC6;SNF8
protein bindingSIGLEC6;CSNK1A1;TRIM67;GAN;PLCG1;MAFB;BMPR2;POLR1A;U2AF2
transcription coactivator activitySERTAD2;PML;UTF1;ING4;MYOD1;PARK7;HINFP;MMS19;CITED2
transcription corepressor activityJUNB;CITED2;TOB1;CDYL;UBP1;AJUBA;HDAC9;AES;SOD3
transcription factor bindingAPBB2;RNF4;HES7;RORA;HMGA2;PIAS1;WWP2;SORBS3;GATA3

SMARCA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMARCA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMARCA4.

ARID1A

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can epigenetic therapies target SMARCA4 alterations? 03/09/2020

Epigenetic therapies that modulate gene expression could indirectly affect SMARCA4-altered cancers, though specific targeting remains a challenge.

Are there diagnostic tests for SMARCA4 mutations? 08/15/2019

Yes, there are genetic tests available to identify SMARCA4 mutations in tumors, aiding in prognosis and treatment decisions.

Are there ongoing clinical trials focusing on SMARCA4 alterations? 01/11/2019

Yes, there are clinical trials exploring new treatment strategies for SMARCA4-altered cancers, aiming to improve patient outcomes.

Is SMARCA4 solely associated with cancer? 04/16/2018

No, SMARCA4's functions extend beyond cancer and have implications in various biological processes, including development and differentiation.

How can SMARCA4 mutations influence patient prognosis? 01/31/2018

Patients with SMARCA4 mutations in their tumors often face a poorer prognosis, which necessitates tailored treatment approaches.

Customer Reviews (3)

Write a review
Reviews
02/18/2023

    The SMARCA4 protein offers exceptional quality that meets the rigorous demands of experimental research.

    11/01/2018

      It exhibits exceptional performance in ELISA assays, making it an excellent choice for researchers studying angiopoietins, angiogenesis, or vascular biology.

      10/30/2016

        Its purity, consistency, and reliable performance make it a top choice for a wide range of applications.

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