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SMARCC2

Official Full Name

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
Overview

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms

SMARCC2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2; Rsc8; BAF170; CRACC2; SWI/SNF complex subunit SMARCC2; SWI3-like protein; BRG1-associated factor 170; SWI/SNF complex 170 kDa subunit; chromatin remodeling complex BAF170 subunit; mammalian chromatin remodeling complex BRG1-associated factor 170; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse

Source

HEK293
HEK293T
In Vitro Cell Free System
Mamanlian cells
Wheat Germ

Tag

Flag
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SMARCC2-31424TH	Recombinant Human SMARCC2	Wheat Germ	N/A	1130 amino acids	Inquiry
Human	SMARCC2-2416H	Recombinant Human SMARCC2, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	SMARCC2-1669HCL	Recombinant Human SMARCC2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	SMARCC2-5684HFL	Recombinant Full Length Human SMARCC2, Flag-tagged	Mamanlian cells	Flag		Inquiry
Human	SMARCC2-505HF	Recombinant Full Length Human SMARCC2 Protein	In Vitro Cell Free System		1130 amino acids	Inquiry
Mouse	Smarcc2-5962M	Recombinant Mouse Smarcc2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SMARCC2 Related Articles
SMARCC2 Related Research Area

SMARCC2 involved in several pathways and played different roles in them. We selected most pathways SMARCC2 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Glucocorticoid receptor regulatory network, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMARCC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Chromatin modifying enzymes	SMARCA2;KAT6B;SMARCB1B;GATAD2B;SUZ12B;SAP30L;PADI1;ING5;KDM3B
Chromatin organization	PHF20B;RBBP5;RBBP7;PRMT7;MSL2A;KDM4A;PRMT6;SUZ12B;BRD8
Glucocorticoid receptor regulatory network	CSN2;NR1I3;KRT5;SMARCC2;KRT14;SMARCA4;KRT17;BGLAP;EGR1
Prostate Cancer	MAP4K1;PIK3R3;CREB5;PDGFRA;INSRR;PIK3R5;INS1;PDGFA;GRB2
RMTs methylate histone arginines	WDR77;PBRM1L;PRMT5;ARID2;SMARCD3;SMARCA4;SMARCB1;COPRS;SMARCB1B
TNF-alpha/NF-kB Signaling Pathway	PDCD2;LRPPRC;MCC;COMMD1;DCAF7;SMARCE1;UNC5CL;CAPN3;TANK

SMARCC2 has several biochemical functions, for example, contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding, contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding, contributes_to nucleosomal DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMARCC2 itself. We selected most functions SMARCC2 had, and list some proteins which have the same functions with SMARCC2. You can find most of the proteins on our site.

Function	Related Protein
contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding	SMARCC1;SMARCC2;SMARCB1;HDAC2;CHD4;MTA2;ACTB;GATAD2B;SMARCA4
contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding	SMARCC1;GATAD2B;HDAC1;RBBP4;HDAC2;ACTL6A;ACTB;SMARCC2;SMARCB1
contributes_to nucleosomal DNA binding	RBBP4;SMARCA4;SMARCC1;CHD4;ACTB;MTA2;SMARCC2;GATAD2B;SMARCB1
protein binding	ANG;ZW10;TRAF3IP1;TDO2;TUBA3C;GBP2;TGFB3;NCBP1;BDKRB1
transcription coactivator activity	THRAP3;MED12;MED16;UTF1;MAGED1;TADA2B;GTF2F1;TAF7L;GTF2A2

SMARCC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMARCC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMARCC2.

SMARCA4; NCOR1

Wang, XM; Liao, DW; et al. Monoclonal antibodies reactive with the BAF155 (SMARCC1) and BAF170 (SMARCC2) components of human SWI/SNF-related complexes. HYBRIDOMA 24:55-57(2005).

SWI/SNF Family