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SMC3

  • Official Full Name

    structural maintenance of chromosomes 3

  • Overview

    This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]
  • Synonyms

    SMC3; structural maintenance of chromosomes 3; BAM; BMH; HCAP; CDLS3; CSPG6; SMC3L1; structural maintenance of chromosomes protein 3; SMC protein 3; chromosome-associated polypeptide; chondroitin sulfate proteoglycan 6 (bamacan); basement membrane-associated chondroitin proteoglycan;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Zebrafish
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SMC3-20H Recombinant Human SMC3, GST-tagged Wheat Germ GST
Human SMC3-31196TH Recombinant Human SMC3, His-tagged E.coli His
Human SMC3-2810H Recombinant Human SMC3, His-tagged E.coli His 1-349aa
Human SMC3-1541H Recombinant Human SMC3 protein, His & T7-tagged E.coli His/T7 Ser994~Glu1181 (Accession # Q9UQE7)
Human SMC3-1648HCL Recombinant Human SMC3 cell lysate N/A
Human SMC3-6688H Recombinant Human SMC3 Protein (Glu995-Glu1181), N-His tagged E.coli N-His Glu995-Glu1181
Zebrafish SMC3-12720Z Recombinant Zebrafish SMC3 Mammalian Cell His
Chicken SMC3-6086C Recombinant Chicken SMC3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SMC3 Related Articles

SMC3 involved in several pathways and played different roles in them. We selected most pathways SMC3 participated on our site, such as Cell cycle, Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell cycleLIN37;AKAP9;GADD45A;SMARCA5;SDCCAG8;MAD1L1;CEP152;SMAD3;CCNB3
Oocyte meiosisFBXW11;REC8B;MAD2L1;CALM1A;PRKACA;INS2;MOS;IGF1RA;RPS6KA3

SMC3 has several biochemical functions, for example, ATP binding, chromatin binding, dynein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMC3 itself. We selected most functions SMC3 had, and list some proteins which have the same functions with SMC3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDDX19A;TDRD12;CKBA;AK5;CAMK1DA;UBE2I;ABCB10;ATP1A1A.3;PGK1
chromatin bindingBCL6;CDK9;SOX9A;POLA1;PBRM1;URI1;TP63;MSL1;PBRM1L
dynein bindingDCTN1;DNAAF1;SNCA;KATNB1;SERPINB1A;PAFAH1B1B;PAFAH1B1;LRRC50;BICD1
mediator complex bindingSMC1A;MED1;SMC3;NIPBL
microtubule motor activityDYNC1I2;DNALI1;KIF3CB;KIF7;KIF2C;KLC4;KLC3;DNAHC8;KIF4
protein bindingDCP2;NT5C2;GPS1;DNM1L;HTR1B;SNX19;TAF1A;SLC6A20;TBL1X
protein heterodimerization activityMEF2A;ZHX3;TAS1R1;SDCBP;RARA;USF1;TAF4B;HIST1H4J;MYF6

SMC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMC3.

RAD21; STAG1

Bermudez, VP; Farina, A; et al. In vitro loading of human cohesin on DNA by the human Scc2-Scc4 loader complex. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109:9366-9371(2012).
del Cacho, E; Gallego, M; et al. Location of RAD51-like protein during meiotic prophase in Eimeria tenella. VETERINARY PARASITOLOGY 178:77-85(2011).
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