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SMG6

  • Official Full Name

    SMG6 nonsense mediated mRNA decay factor

  • Overview

    This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. [provided by RefSeq, Feb 2014]
  • Synonyms

    SMG6; SMG6 nonsense mediated mRNA decay factor; EST1A; SMG-6; C17orf31; hSMG5/7a; telomerase-binding protein EST1A; telomerase subunit EST1A; ever shorter telomeres 1A; EST1 telomerase component homolog A; smg-6 homolog, nonsense mediated mRNA decay factor;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Mouse SMG6-15624M Recombinant Mouse SMG6 Protein Mammalian Cell His
Mouse SMG6-8479M Recombinant Mouse SMG6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SMG6-8479M-B Recombinant Mouse SMG6 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SMG6 Related Articles

SMG6 involved in several pathways and played different roles in them. We selected most pathways SMG6 participated on our site, such as mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMG6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
mRNA surveillance pathwayCPSF7;PPP2R2BB;PABPC1;BAT1;PPP2R5D;PPP1CAA;SMG5;BCL2L2-PABPN1;PPP1CBL

SMG6 has several biochemical functions, for example, DNA binding, T/G mismatch-specific endonuclease activity, endonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SMG6 itself. We selected most functions SMG6 had, and list some proteins which have the same functions with SMG6. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZNF468;POU2F1A;ERCC2;ZNF511;POU3F3B;CERS4;TRIM30A;Rhox5;ZNF326
T/G mismatch-specific endonuclease activityZRANB3;RAG1;REXO1;TMPPE;REXO4;MEIOB;SMG6;GDPD4;ENDOU2
endonuclease activityRAG1;ENDOU2;RNASEKA;DROSHA;PMS2;DNASE2A;EAR2;ENDOG;DCLRE1C
endoribonuclease activityPLD6;RNASEKA;RNASEKB;ENDOU;DICER1;CPSF3;RNASEK;ENDOU2;AGO2
hydrolase activityACOT10;Gzmd;EAR3;Casp3;GGT7;FAHD2B;PPM1E;ENTPD2A.1;PTPN4A
metal ion bindingZNF277;TRIM35-31;LMO7B;ALPL;ZNF565;ZNF296;MARCH4;RHOU;MOBKL2B
nuclease activityRNASEL4;TMPPE;RNASEKA;DROSHA;EXOSC9;EAR1;DNASE1L3L;MEIOB;RNASEL3
phosphoric ester hydrolase activityEXO5;FBP1A;ENDOU2;FBP1B;SACM1L;ZRANB3;SYNJ1;REXO1;MEIOB
retroviral 3 processing activityENDOU2;GDPD4;TMPPE;SMG6;EXO5;RNASEKB;MEIOB;ZRANB3;REXO1
telomeric DNA bindingPOT1A;TINF2;SMG6;OBFC1;TERF1;TP53BP1;TERF2;TEN1;TERT

SMG6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMG6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMG6.

Schmidt, SA; Foley, PL; et al. Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells. NUCLEIC ACIDS RESEARCH 43:309-323(2015).
Wilusz, JE; Wilusz, J; et al. Nonsense-mediated RNA decay: at the 'cutting edge' of regulated snoRNA production. GENES & DEVELOPMENT 28:2447-2449(2014).
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