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SMG7

Official Full Name

SMG7 nonsense mediated mRNA decay factor
Overview

This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]
Synonyms

SMG7; SMG7 nonsense mediated mRNA decay factor; EST1C; SGA56M; C1orf16; protein SMG7; EST1-like protein C; ever shorter telomeres 1C; EST1 telomerase component homolog C; breast cancer-associated antigen SGA-56M; smg-7 homolog, nonsense mediated mRNA decay factor;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SMG7-3947H	Recombinant Human SMG7 protein, His-tagged	E.coli	His	201-500 aa	$319 / 25ug
Mouse	SMG7-15625M	Recombinant Mouse SMG7 Protein	Mammalian Cell	His		Inquiry
Mouse	SMG7-8480M	Recombinant Mouse SMG7 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	SMG7-8480M-B	Recombinant Mouse SMG7 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	SMG7-4134Z	Recombinant Zebrafish SMG7	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SMG7 Related Articles

SMG7 involved in several pathways and played different roles in them. We selected most pathways SMG7 participated on our site, such as mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMG7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
mRNA surveillance pathway	PABPC3;PPP2R5B;CASC3;PPP1CC;GSPT1;ETF1B;GSPT1L;CPSF3;CSTF2T

SMG7 has several biochemical functions, for example, protein phosphatase 2A binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMG7 itself. We selected most functions SMG7 had, and list some proteins which have the same functions with SMG7. You can find most of the proteins on our site.

Function	Related Protein
protein phosphatase 2A binding	SPHK1;TRP53;PPP2R2A;BCL2;SHC1;IGBP1;HMGCR;CPD;CTTNBP2NL

SMG7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMG7 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMG7.

Balistreri, G; Horvath, P; et al. The Host Nonsense-Mediated mRNA Decay Pathway Restricts Mammalian RNA Virus Replication. CELL HOST & MICROBE 16:403-411(2014).

Kurosaki, T; Li, WC; et al. A post-translational regulatory switch on UPF1 controls targeted mRNA degradation. GENES & DEVELOPMENT 28:1900-1916(2014).