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SMPD4

  • Official Full Name

    sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)

  • Overview

    Sphingomyelinases (EC 3.1.4.12), such as SMPD4, catalyze the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (Krut et al., 2006 (PubMed 16517606)).
  • Synonyms

    SMPD4; sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3); sphingomyelin phosphodiesterase 4; FLJ20297; FLJ20756; KIAA1418; NET13; nSMase 3; NSMASE3; Neutral sphingomyelinase 3; Neutral sphingomyelinase III; NSMA3_HUMAN; nSMase-3; OTTHUMP00000162391; OTTHUMP00000190862; SKNY protein; Sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase 3);

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Danio rerio (Zebrafish) (Brachydanio rerio)
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SMPD4-2821H Recombinant Human SMPD4, His-tagged E.coli His 1-350aa
Human SMPD4-2709H Recombinant Human SMPD4 Protein, His-tagged E.coli N-His Ala10-His148
Mouse SMPD4-15642M Recombinant Mouse SMPD4 Protein Mammalian Cell His
Mouse Smpd4-2087M Recombinant Mouse Smpd4 Protein, His-tagged E.coli N-His Met1-Phe185
Mouse SMPD4-8496M Recombinant Mouse SMPD4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SMPD4-8496M-B Recombinant Mouse SMPD4 Protein Pre-coupled Magnetic Beads HEK293
Danio rerio (Zebrafish) (Brachydanio rerio) RFL7148DF Recombinant Full Length Danio Rerio Sphingomyelin Phosphodiesterase 4(Smpd4) Protein, His-Tagged E.coli expression system His Full Length (1-791)
Zebrafish SMPD4-12535Z Recombinant Zebrafish SMPD4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

SMPD4 involved in several pathways and played different roles in them. We selected most pathways SMPD4 participated on our site, such as Sphingolipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMPD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Sphingolipid metabolismASAH2;SPTLC3;PPM1L;SPHK2;ARSK;KDSR;SPTLC1;LASS2;LASS1
Metabolic pathwaysBDH1;ATP6V1BA;MAT2AL;TYMP;RRM2B;PKM2;RDH11;CES1D;CYP51A1

SMPD4 has several biochemical functions, for example, metal ion binding, sphingomyelin phosphodiesterase D activity, sphingomyelin phosphodiesterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SMPD4 itself. We selected most functions SMPD4 had, and list some proteins which have the same functions with SMPD4. You can find most of the proteins on our site.

Function Related Protein
metal ion bindingZFP503;PPP1CA;ZFPM2A;COL5A2;PPM1AB;RASAL1;STEAP1;CD209A;SDHC
sphingomyelin phosphodiesterase D activityR05D11.9;SMPD4
sphingomyelin phosphodiesterase activitySMPD2;SMPD4;SMPD5;SMPD3;ENPP7;SMPD2A;SMPDL3B;SMPD1;SMPDL3A

SMPD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMPD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMPD4.

BRF2; EXOSC4; E2F3

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