SMYD2
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Official Full Name
SET and MYND domain containing 2
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Overview
SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 (PubMed;16805913)). -
Synonyms
SMYD2; SET and MYND domain containing 2; N-lysine methyltransferase SMYD2; HSKM B; KMT3C; ZMYND14; lysine N-methyltransferase 3C; histone methyltransferase SMYD2; zinc finger, MYND domain containing 14; SET and MYND domain-containing protein 2; HSKM-B; MG;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E. coli
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- SMYD2 Related Articles
- SMYD2 Related Research Area
SMYD2 involved in several pathways and played different roles in them. We selected most pathways SMYD2 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, PKMTs methylate histone lysines, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMYD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin modifying enzymes | PHF20B;SUZ12;C20orf20;TADA2B;ARID2;KDM2AA;KDM2B;RBBP5;ATXN7L3 |
| Chromatin organization | MSL3;ARID4A;ATXN7L3;RUVBL2;BRD1;PHF8;KANSL2;PADI6;ANO9A |
| PKMTs methylate histone lysines | SMYD3;DPY30;SUZ12B;SUZ12A;EHMT2;ATF7IP;AEBP2;SETD3;RBBP5 |
| p53 pathway | HUWE1;FBXO11;PPP1R13L;CSE1L;SMYD2;NEDD8;KAT8;CSNK1G3;DYRK2 |
SMYD2 has several biochemical functions, for example, RNA polymerase II core binding, histone methyltransferase activity (H3-K36 specific), metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMYD2 itself. We selected most functions SMYD2 had, and list some proteins which have the same functions with SMYD2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core binding | WACA;SMYD2B;SMYD3;ZFP326;PCF11;KIAA1967;SMYD2A;CTR9;CDC73 |
| histone methyltransferase activity (H3-K36 specific) | ASH1L;SMYD2B;SMYD2;SETD3;NSD1;SMYD2A;SETMAR;SETD2 |
| metal ion binding | NADK;ATP13A;PLEKHM3;ACLY;RAG1;NKD2B;ZNF792;CSK;TRIM43B |
| p53 binding | ZNF385B;CDKN2A;GATA1;SETD7;DAXX;CREBBP;HSPD1;ZMAT4;SIRT1 |
| protein binding | VPS18;DCC;KATNA1;NR2C2AP;RNF138;GNS;DUSP14;CTSG;NR3C1 |
| protein-lysine N-methyltransferase activity | METTL20;FBLL1;METTL21A;SETD8;SETD7;METTL8;NDUFAF5;METTL21C;VCPKMT |
SMYD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMYD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMYD2.
GEMIN2; AXIN1; VPS26A; EIF4E; SNRPB2; MYH1; MYH6; HNRNPL; PEBP1; GSK3B; RPS14; RPL23A; PTGES3; SF3A1; CDC37
- Q&As
- Reviews
Q&As (5)
Ask a questionInvestigations into small molecules and inhibitors targeting SMYD2 are underway, with potential applications in cancer and cardiovascular disease treatment.
Monitoring SMYD2 levels may provide insights into the progression of cardiovascular diseases, aiding in early diagnosis and treatment.
Research suggests that SMYD2 may play a role in neurodegenerative diseases, and exploring its modulation could offer new avenues for therapeutic intervention.
SMYD2 is involved in various cellular processes, including cell cycle regulation, DNA repair, and inflammation, making it a versatile protein with potential implications in multiple diseases.
SMYD2 has been linked to cardiac hypertrophy and heart failure, suggesting its potential as a therapeutic target in the context of cardiovascular diseases.
Customer Reviews (3)
Write a reviewIts compatibility with various methodologies further enhances its value as a research tool, making it a go-to choice for investigating SMYD2 protein function and molecular interactions.
The versatility of the SMYD2 protein extends beyond these applications, enabling its use in a wide range of experimental techniques.
the SMYD2 protein stands out for its exceptional quality and its ability to fulfill my experimental requirements.
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