Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

SNCAIP

Official Full Name

synuclein, alpha interacting protein
Overview

Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1.
Synonyms

SNCAIP; synuclein, alpha interacting protein; Sph1; SYPH1; MGC39814; synphilin-1; OTTHUMP00000159162; OTTHUMP00000159163; OTTHUMP00000222988; alpha-synuclein-interacting protein; synphilin;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SNCAIP-2838H	Recombinant Human SNCAIP, GST-tagged	E.coli	GST	C-term-351aa	$319 / 25ug
Human	SNCAIP-1633HCL	Recombinant Human SNCAIP 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	Sncaip-5997M	Recombinant Mouse Sncaip Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rat	Sncaip-8118R	Recombinant Rat Sncaip protein, His & GST-tagged	E.coli	His/GST	Pro766~Leu963 (Accession # D3ZWQ5)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
SNCAIP Related Articles

SNCAIP involved in several pathways and played different roles in them. We selected most pathways SNCAIP participated on our site, such as Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNCAIP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Parkinsons disease	NDUFB4;APAF1;NDUFV3;NDUFC2;SNCA;SLC25A6;NDUFS7;ATP5B;SLC25A4

SNCAIP has several biochemical functions, for example, identical protein binding, protein binding, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNCAIP itself. We selected most functions SNCAIP had, and list some proteins which have the same functions with SNCAIP. You can find most of the proteins on our site.

Function	Related Protein
identical protein binding	ACY3;MBIP;SRI;C1QL2;COIL;SERPINA1A;PFKFB1;ZDHHC17;ZNF212
protein binding	DSCAM;GPM6A;IGF1;TMF1;EEF2;NEU4;ATPAF1;SMN1;TTC37
ubiquitin protein ligase binding	TNFRSF14;TMEM189;CUL1B;SMC6;HSPA5;PRKACA;TMBIM6;RALB;DNM1L

SNCAIP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNCAIP here. Most of them are supplied by our site. Hope this information will be useful for your research of SNCAIP.

SNCA

Jeffries, MA; Donica, M; et al. Genome-Wide DNA Methylation Study Identifies Significant Epigenomic Changes in Osteoarthritic Cartilage. ARTHRITIS & RHEUMATOLOGY 66:2804-2815(2014).

Gylfe, AE; Kondelin, J; et al. Identification of Candidate Oncogenes in Human Colorectal Cancers With Microsatellite Instability. GASTROENTEROLOGY 145:540-+(2013).