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SNCB

  • Official Full Name

    synuclein, beta

  • Overview

    The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene.
  • Synonyms

    SNCB; synuclein, beta; beta-synuclein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SNCB-84H Recombinant Human Synuclein, Beta E.coli N/A
Human SNCB-2839H Recombinant Human SNCB, GST-tagged E.coli GST 1-134
Human SNCB-246H Recombinant Human SNCB, His-tagged E.coli His
Human SNCB-1631HCL Recombinant Human SNCB 293 Cell Lysate HEK293 N/A
Human SNCB-1632HCL Recombinant Human SNCB 293 Cell Lysate HEK293 N/A
Human SNCB-1294HFL Recombinant Full Length Human SNCB Protein, C-Flag-tagged Mammalian cells Flag
Human SNCB-245H Recombinant Human SNCB Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SNCB-2056H Recombinant Human SNCB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SNCB-27206TH Native Human SNCB E.coli N/A
Human SNCB-2056H-B Recombinant Human SNCB Protein Pre-coupled Magnetic Beads HEK293
Human SNCB-5006H Recombinant Human SNCB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse SNCB-2457M Recombinant Mouse SNCB Protein (1-133 aa) E.coli N/A 1-133 aa
Mouse Sncb-249M Recombinant Mouse Sncb Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat SNCB-5639R Recombinant Rat SNCB Protein Mammalian Cell His
Rat SNCB-5298R Recombinant Rat SNCB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SNCB-5298R-B Recombinant Rat SNCB Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SNCB-4366R Recombinant Rhesus monkey SNCB Protein, His-tagged Mammalian Cell His
Rhesus Macaque SNCB-4182R Recombinant Rhesus Macaque SNCB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SNCB-4182R-B Recombinant Rhesus Macaque SNCB Protein Pre-coupled Magnetic Beads HEK293
Zebrafish SNCB-11204Z Recombinant Zebrafish SNCB Mammalian Cell His
Chicken SNCB-6237C Recombinant Chicken SNCB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SNCB Related Articles
  • SNCB Related Research Area

SNCB involved in several pathways and played different roles in them. We selected most pathways SNCB participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SNCB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

SNCB has several biochemical functions, for example, calcium ion binding, phospholipase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SNCB itself. We selected most functions SNCB had, and list some proteins which have the same functions with SNCB. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingVIL1;ANXA1A;SRI;RASGRP3;PVALB6;MICU2;CDH9;PSPH;DOC2B
phospholipase inhibitor activityANXA3B;SNCB;ANXA3A;ANXA5;ANXA2B;ANXA1C;ANXA1B;ANXA4;ANXA2A

SNCB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNCB here. Most of them are supplied by our site. Hope this information will be useful for your research of SNCB.

SNCAIP; AKT1; CENPT

Viola, KL; Klein, WL; et al. Amyloid beta oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis. ACTA NEUROPATHOLOGICA 129:183-206(2015).
Mukaetova-Ladinska, EB; Abdel-All, Z; et al. Tau Proteins in the Temporal and Frontal Cortices in Patients With Vascular Dementia. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 74:148-157(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any genetic mutations associated with SNCB protein that contribute to neurodegenerative diseases? 03/27/2021

Mutations in the SNCB gene have been identified in certain cases of familial Parkinson's disease, suggesting a genetic link to the disease.

Are there any imaging techniques that can visualize SNCB protein aggregates in the brain? 01/12/2021

Positron emission tomography (PET) imaging using specific radiotracers has shown promise in visualizing SNCB protein aggregates in the brain.

How does SNCB protein interact with other proteins in the brain? 05/13/2018

SNCB protein has been found to interact with alpha-synuclein and other proteins in the brain, potentially influencing disease pathogenesis.

What are the future directions for research on the clinical application of SNCB protein? 03/02/2017

Future research directions include further validation of SNCB protein as a biomarker, development of targeted therapeutic interventions, and understanding the molecular mechanisms underlying its role in neurodegenerative diseases.

How do fluctuations in SNCB protein levels correlate with disease progression in neurodegenerative diseases? 01/22/2016

Studies have suggested that alterations in SNCB protein levels may correlate with disease severity and progression in neurodegenerative diseases.

Customer Reviews (3)

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Reviews
01/30/2019

    Highly recommended!

    06/22/2018

      The SNCB protein is undoubtedly a superior choice, boasting extraordinary quality that guarantees it will fulfill all my experimental requirements.

      11/14/2016

        Their team of experts is highly knowledgeable, responsive, and dedicated to providing prompt solutions to any challenges I may face.

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