SNCB
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Official Full Name
synuclein, beta
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Overview
The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene. -
Synonyms
SNCB; synuclein, beta; beta-synuclein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- SNCB Related Articles
- SNCB Related Research Area
SNCB involved in several pathways and played different roles in them. We selected most pathways SNCB participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SNCB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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SNCB has several biochemical functions, for example, calcium ion binding, phospholipase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SNCB itself. We selected most functions SNCB had, and list some proteins which have the same functions with SNCB. You can find most of the proteins on our site.
Function | Related Protein |
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calcium ion binding | VIL1;ANXA1A;SRI;RASGRP3;PVALB6;MICU2;CDH9;PSPH;DOC2B |
phospholipase inhibitor activity | ANXA3B;SNCB;ANXA3A;ANXA5;ANXA2B;ANXA1C;ANXA1B;ANXA4;ANXA2A |
SNCB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNCB here. Most of them are supplied by our site. Hope this information will be useful for your research of SNCB.
SNCAIP; AKT1; CENPT
- Q&As
- Reviews
Q&As (5)
Ask a questionMutations in the SNCB gene have been identified in certain cases of familial Parkinson's disease, suggesting a genetic link to the disease.
Positron emission tomography (PET) imaging using specific radiotracers has shown promise in visualizing SNCB protein aggregates in the brain.
SNCB protein has been found to interact with alpha-synuclein and other proteins in the brain, potentially influencing disease pathogenesis.
Future research directions include further validation of SNCB protein as a biomarker, development of targeted therapeutic interventions, and understanding the molecular mechanisms underlying its role in neurodegenerative diseases.
Studies have suggested that alterations in SNCB protein levels may correlate with disease severity and progression in neurodegenerative diseases.
Customer Reviews (3)
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