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SNW1

Official Full Name

SNW domain containing 1
Overview

This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.
Synonyms

SNW1; SNW domain containing 1; SKI interacting protein , SKIIP; SNW domain-containing protein 1; Bx42; NCoA 62; Prp45; PRPF45; SKIP; Bx 42; Homolog of Drosophila BX42; MGC119379; Nuclear protein SkiP; Nuclear receptor coactivator 62 kD; Nuclear receptor coactivator NCoA 62; Nuclear receptor coactivator NCoA62; Prp 45; PRPF 45; Ski interacting protein; SKIIP; SNW 1; SNW domain containing protein 1; SNW1 protein; SKI-interacting protein; nuclear receptor coactivator, 62-kD; nuclear receptor coactivator NCoA-62; NCOA-62;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	SNW1-29295TH	Recombinant Human SNW1, His-tagged	E.coli	His	Inquiry
Human	SNW1-618HCL	Recombinant Human SNW1 lysate	HEK293	N/A	Inquiry
Zebrafish	SNW1-852Z	Recombinant Zebrafish SNW1	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein

SNW1 involved in several pathways and played different roles in them. We selected most pathways SNW1 participated on our site, such as Spliceosome, Notch signaling pathway, Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNW1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Spliceosome	WBP11;PRPF19;NHP2L1B;SRSF2;MAGOH2;SRSF2B;SART1;HNRNPA1L2;THOC4
Notch signaling pathway	TLE3A;DLC;NUMBL;CNTN6;DTX1;JAG1B;DTX2;APH1B;DLK1
Epstein-Barr virus infection	PIK3R3;POLR2B;CSNK2A2;POLR3C;MAP3K14;EIF2AK4;HLA-DQA1;TNFAIP3;CDK1
Viral carcinogenesis	GTF2A1;C3;HLA-E;HLA-G;CCND1;STAT5B;HIST1H2BD;EIF2AK2;NFKB1

SNW1 has several biochemical functions, for example, Notch binding, SMAD binding, nuclear hormone receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNW1 itself. We selected most functions SNW1 had, and list some proteins which have the same functions with SNW1. You can find most of the proteins on our site.

Function	Related Protein
Notch binding	HIF1AN;JAG1;SNW1;ADAM17;NOTCH1;JAG1B;JAG2;GALNT11;DLL3
SMAD binding	SKI;BMPR1B;COL5A2;PRDM16;SMAD2;EID2;ACVR1B;SOD3;TGFBRAP1
nuclear hormone receptor binding	TCF7L2;Ankar;EP300;CRY1;CRX;SMARCD3;ACTN4;NRIP1;MYOD1
poly(A) RNA binding	RBM22;HMGN2;PURB;H1FX;PEG10;RBM34;SUB1;RRP9;YTHDF3
protein binding	UBE2L3;TPP2;ST13;SPARC;TAF1B;ADCK5;CDK10;HLA-DRB4;FAM115A
retinoic acid receptor binding	HMGA1-RS1;PRAMEF6;ASXL1;NSD1;PRAME;LRIF1;PRAMEF10;PRMT2;RXRA
transcription coactivator activity	ARID1A;BRCA1;MED6;SMARCE1;YAP1;JUN;NR1H3;ARL2BP;MED17
transcription corepressor activity	HSBP1;RARA;DDX54;NOC2L;IRF2BP2;CDYL;ZMYND11;CDX2;TOB1
vitamin D receptor binding	MED16;MED17;THRAP3;MED14;RXRA;TAF7;MED30;TAF11;MED1

SNW1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNW1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNW1.

PPIL1; SNIP1; PABPN1