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ARID4B

  • Official Full Name

    AT rich interactive domain 4B (RBP1-like)

  • Overview

    This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized
  • Synonyms

    ARID4B; AT rich interactive domain 4B (RBP1-like); AT rich interactive domain 4B (RBP1 like) , RBP1L1, retinoblastoma binding protein 1 like 1; AT-rich interactive domain-containing protein 4B; BCAA; BRCAA1; SAP180; Rb-binding protein homolog; SIN3A-ass; SOLH; small optic lobes homolog (Drosophila); CAPN15; MGC131491; calpain-15; OTTHUMP00000147599; small optic lobes (Drosophila) homolog;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SOLH-27401TH Recombinant Human SOLH Wheat Germ N/A 94 amino acids
Human ARID4B-3550H Recombinant Human ARID4B protein, His-tagged E.coli His 406-523 aa
Human ARID4B-3658H Recombinant Human ARID4B protein, GST-tagged E.coli GST 406-523 aa
Human ARID4B-4497H Recombinant Human ARID4B protein, His-tagged E.coli His 167-415aa
Mouse Arid4b-3681M Recombinant Mouse Arid4b, His-tagged E.Coli or Yeast His 1314
Mouse ARID4B-1915M Recombinant Mouse ARID4B Protein Mammalian Cell His
Mouse SOLH-15754M Recombinant Mouse SOLH Protein Mammalian Cell His
Mouse ARID4B-709M-B Recombinant Mouse ARID4B Protein Pre-coupled Magnetic Beads HEK293
Mouse ARID4B-709M Recombinant Mouse ARID4B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ARID4B-775R Recombinant Rat ARID4B Protein Mammalian Cell His
Rat ARID4B-431R-B Recombinant Rat ARID4B Protein Pre-coupled Magnetic Beads HEK293
Rat ARID4B-431R Recombinant Rat ARID4B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ARID4B Related Articles

ARID4B involved in several pathways and played different roles in them. We selected most pathways ARID4B participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ARID4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ARID4B has several biochemical functions, for example, DNA binding, protein binding, transcription regulatory region DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARID4B itself. We selected most functions ARID4B had, and list some proteins which have the same functions with ARID4B. You can find most of the proteins on our site.

Function Related Protein
DNA bindingSTAT1B;SSRP1;HOXD3A;BRCA1;ZFP653;ZNF280A;BRD4;ESRRA;ZNF383
protein bindingCORO1B;WDR25;PAWR;ACSF2;MT1H;ODC1;C1orf21;PUM2;MYL2
transcription regulatory region DNA bindingZNF613;NKX3;IKZF1;ZFHX3;PROX1;IKZF2;ETV5;BCL11B;TAL1

ARID4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARID4B here. Most of them are supplied by our site. Hope this information will be useful for your research of ARID4B.

Liangpunsakul, S; Lai, XY; et al. Novel Serum Biomarkers for Detection of Excessive Alcohol Use. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 39:556-565(2015).
Goldberger, N; Walker, RC; et al. Inherited Variation in miR-290 Expression Suppresses Breast Cancer Progression by Targeting the Metastasis Susceptibility Gene Arid4b. CANCER RESEARCH 73:2671-2681(2013).
  • Q&As
  • Reviews

Q&As (17)

Ask a question
Is ARID4B involved in any diseases or conditions? 07/18/2022

Dysregulation of ARID4B has been implicated in various diseases and conditions. It has been found to be dysregulated in certain cancers, including breast, lung, and colorectal cancer, where it can contribute to tumor growth and metastasis. Additionally, ARID4B has been associated with neurodevelopmental disorders and intellectual disabilities, where mutations or alterations in ARID4B gene expression have been found in affected individuals.

What other proteins does ARID4B interact with? 02/07/2022

ARID4B can interact with a range of proteins to carry out its functions. It has been found to interact with components of chromatin remodeling complexes, including histone deacetylases (HDACs) and the Sin3A co-repressor complex. ARID4B can also interact with other transcription factors and regulatory proteins to modulate gene expression.

What research techniques are commonly used to study ARID4B? 12/31/2021

Researchers commonly use techniques such as chromatin immunoprecipitation (ChIP) and sequencing (ChIP-seq), which allow them to identify genomic regions where ARID4B binds to DNA. They also use techniques like RNA-sequencing and gene expression analysis to study the effect of ARID4B on gene regulation. Additionally, cell culture experiments and animal models are utilized to investigate the functional roles of ARID4B in specific cellular processes and disease contexts.

Is ARID4B associated with any specific diseases or conditions? 09/10/2021

Yes, ARID4B has been associated with several diseases and conditions. For example, mutations or deletions in the ARID4B gene have been found in individuals with Coffin-Siris syndrome, a rare genetic disorder characterized by developmental delays, intellectual disabilities, and distinctive physical features. Additionally, altered expression of ARID4B has been implicated in various types of cancers, including breast, lung, and pancreatic cancer, suggesting its involvement in tumor development and progression.

Does ARID4B have any functional domains besides the DNA-binding domain? 08/31/2021

Yes, ARID4B consists of multiple functional domains. In addition to the ARID domain, it contains a C-terminal domain that is involved in protein-protein interactions. This domain allows ARID4B to interact with other proteins involved in chromatin remodeling and transcriptional regulation.

Are there any known genetic variations or mutations in the ARID4B gene? 08/23/2021

Yes, there have been reported genetic variations and mutations in the ARID4B gene. These variations can lead to altered expression or function of ARID4B and have been associated with certain diseases and conditions, such as intellectual disabilities and cancer.

Is ARID4B expressed in multiple tissues or is it tissue-specific? 07/11/2021

ARID4B is expressed in multiple tissues, although the expression levels may vary across different tissues. It has been detected in various organs and cell types, including the brain, heart, liver, kidney, and immune cells. The expression of ARID4B may also be regulated during different stages of development or in response to specific signals or stimuli.

Is ARID4B involved in embryonic development? 09/26/2020

Yes, ARID4B is known to play a role in embryonic development. It is expressed in embryonic tissues and has been shown to be involved in regulating gene expression patterns critical for proper development of tissues and organs.

Can ARID4B be used as a biomarker for any diseases? 09/24/2020

ARID4B has been proposed as a potential biomarker for certain diseases. For example, elevated expression of ARID4B has been associated with poor prognosis in breast cancer patients, suggesting its potential as a prognostic biomarker. However, further studies are needed to validate its clinical utility as a biomarker.

What are the functional domains of ARID4B? 05/18/2020

ARID4B contains several functional domains that contribute to its molecular functions. One of the key domains is the ARID (AT-rich interactive domain), which is responsible for DNA binding and recognition. ARID4B also contains regions that mediate protein-protein interactions, allowing it to interact with other proteins and complexes involved in chromatin remodeling and transcriptional regulation. Additionally, ARID4B has regions that may be involved in nuclear localization, transcriptional activation, or repression, but further research is needed to fully elucidate the functions of these domains.

Can ARID4B bind to DNA? 01/05/2019

Yes, ARID4B can bind to DNA. It contains a DNA-binding domain called an AT-rich interactive domain (ARID), which allows it to interact with specific DNA sequences and regulate gene expression.

Is ARID4B involved in embryonic development? 10/17/2018

Yes, ARID4B has been shown to play a role in embryonic development. Studies in mice have demonstrated that ARID4B is essential for the proper formation of tissues and organs during embryogenesis. Its expression is dynamically regulated during different stages of development, suggesting its involvement in controlling gene expression patterns that are crucial for embryonic development. Furthermore, mutations in ARID4B have been associated with developmental disorders, indicating its importance in normal embryonic development.

Are there any known interacting partners of ARID4B? 03/10/2018

Yes, ARID4B has been found to interact with several other proteins in various cellular processes. It interacts with components of chromatin remodeling complexes, such as the SWI/SNF complex, which regulates gene expression through the modification of chromatin structure. ARID4B has also been shown to interact with transcription factors and co-activators, indicating its involvement in transcriptional regulation.

Are there any drugs or therapies targeting ARID4B? 07/13/2017

Currently, there are no specific drugs or therapies targeting ARID4B. However, as research progresses and our understanding of ARID4B's involvement in diseases deepens, it may become a potential target for therapeutic interventions. Developing targeted therapies for ARID4B will require further investigation into its precise functions, interactions, and mechanisms of action.

Are there any known alternative splicing isoforms of ARID4B? 06/05/2016

Yes, there are alternative splicing isoforms of ARID4B that have been identified. One isoform, called ARID4B-001, is the canonical isoform and is the most widely studied form of ARID4B. However, there are other isoforms, such as ARID4B-002, that have been detected in certain tissues or cell lines. These isoforms may have distinct functions or regulatory roles compared to the canonical isoform, although more research is needed to fully understand their specific functions.

Can ARID4B regulate gene expression both positively and negatively? 05/05/2016

Yes, ARID4B has been found to have both positive and negative regulatory effects on gene expression. It can act as a transcriptional co-activator, recruiting chromatin remodeling complexes to promote gene activation. On the other hand, ARID4B can also function as a transcriptional repressor by interacting with specific proteins or complexes that inhibit gene expression. The regulatory role of ARID4B depends on its interactions with other proteins and the specific context of the target gene.

Are there any drugs or therapies targeting ARID4B? 04/09/2016

Currently, there are no specific drugs or therapies targeting ARID4B. However, ongoing research on the role of ARID4B in diseases like cancer may lead to the development of targeted therapies in the future.

Customer Reviews (8)

Write a review
Reviews
03/09/2023

    Its high sensitivity enables the identification of low abundance targets, making it highly valuable in immunological research.

    02/13/2023

      researchers have found ARID4B protein to be highly suitable for protein electron microscopy structure analysis.

      07/10/2021

        Researchers who have utilized ARID4B protein praise its exceptional performance and reliability in their experiments.

        02/16/2021

          It minimizes the risk of protein degradation and maximizes the effectiveness of the protein in various applications, such as cell signaling pathways or metabolic studies.

          07/29/2019

            This stability is particularly advantageous for long-term studies or experiments involving extended incubation periods.

            06/21/2018

              Its high level of consistency allows for precise measurements and accurate data interpretation, enhancing the reliability of my findings.

              08/05/2016

                The manufacturer's deep understanding of the protein and its applications enables them to promptly and effectively address any issues that may arise during my trials.

                06/17/2016

                  ARID4B protein's ability to maintain structural integrity during imaging facilitates the detailed visualization of protein complexes and their interactions.

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