SORD
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Official Full Name
sorbitol dehydrogenase
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Overview
Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 (PubMed 8535074)). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor. -
Synonyms
SORD; sorbitol dehydrogenase; L-iditol 2-dehydrogenase; SORD1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cattle
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- C
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- SORD Related Articles
SORD involved in several pathways and played different roles in them. We selected most pathways SORD participated on our site, such as Pentose and glucuronate interconversions, Fructose and mannose metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with SORD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Pentose and glucuronate interconversions | UGT1A7C;UGT5G1;UGP2;ALDH2.2;AKR1B8;RPE;UGT2B7;AKR1B1;GUSB |
Fructose and mannose metabolism | MPI;HK2;FBP2;PFKFB3;TPI1B;PMM1;PFKMA;ALDOB;ALDOAA |
Metabolic pathways | FBP1;HPGDS;LALBA;ADC;COX5B;POLR2G;TPH2;STT3B;GALNT10 |
SORD has several biochemical functions, for example, D-xylulose reductase activity, L-iditol 2-dehydrogenase activity, NAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SORD itself. We selected most functions SORD had, and list some proteins which have the same functions with SORD. You can find most of the proteins on our site.
Function | Related Protein |
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D-xylulose reductase activity | |
L-iditol 2-dehydrogenase activity | |
NAD binding | GRHPRA;ADH1;IDH3G;CYB5R3;GPD1;NNT;NDUFV1;AOX1;GPD1C |
carbohydrate binding | CLEC2H;KLRC1;GALNT6;KLRA8;KLRB1A;GALNT9;CNTN2;FCN1;KLRD1 |
identical protein binding | ZNF703;PPPDE2;SEPT7;CEP170L;CIDEB;MICU1;HACL1;PUF60;LRRK1 |
zinc ion binding | MMP11;JADE1;BIRC3;BPTF;CPN1;PHC2;FTR72;AKAP8;MAN2C1 |
SORD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SORD here. Most of them are supplied by our site. Hope this information will be useful for your research of SORD.
GH1; TNIK; RELA; MYH9; ANLN; PDLIM7; CFAP97
- Q&As
- Reviews
Q&As (6)
Ask a questionAt present, the association between SORD protein and disease is not well understood, and further research is needed to explore its role in specific diseases.
SORD protein is involved in the antioxidant process in cells, and may indirectly affect the antioxidant capacity in cells by regulating heptitol-6-phosphate metabolism.
There is no clear information on the association between SORD protein mutations and inherited diseases.
There is no evidence that the lack of SORD protein function directly leads to the development of disease. However, it may affect the normal function of the glucose metabolism pathway.
The protein may play a role in metabolic pathways related to metabolic diseases (e.g., diabetes mellitus and metabolic syndrome), but the specific relationship still needs to be further studied.
SORD protein is involved in the heptylol-6-phosphoreductase reaction in the glucose metabolism pathway, which converts heptitol-6-phosphate to cholesterol alcohol.
Customer Reviews (3)
Write a reviewThe stability of SORD products allows them to cope with different experimental conditions and modes of operation.
SORD has a high specific activity and can exert strong biological effects at low concentrations.
When experiments were performed with SORD, the reproducibility of the results was excellent.
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