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SORD

  • Official Full Name

    sorbitol dehydrogenase

  • Overview

    Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 (PubMed 8535074)). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.
  • Synonyms

    SORD; sorbitol dehydrogenase; L-iditol 2-dehydrogenase; SORD1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SORD-29H Active Recombinant Human SORD Protein E.coli N/A
Human SORD-30012TH Recombinant Human SORD, His-tagged E.coli His
Human SORD-2490H Recombinant Human Sorbitol Dehydrogenase, His-tagged E.coli His
Human SORD-2878H Recombinant Human SORD, His-tagged E.coli His 1-357aa
Human SORD-1569HCL Recombinant Human SORD 293 Cell Lysate HEK293 N/A
Human SORD-6334H Recombinant Human SORD Protein (Ala2-Pro357), C-His tagged Mammalian cells C-His Ala2-Pro357
Human SORD-5389H Recombinant Human SORD Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SORD-6335H Recombinant Human SORD Protein (Ala98-Gln355), N-His tagged E.coli N-His Ala98-Gln355
Mouse SORD-15762M Recombinant Mouse SORD Protein Mammalian Cell His
Mouse Sord-6046M Recombinant Mouse Sord Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse SORD-8575M-B Recombinant Mouse SORD Protein Pre-coupled Magnetic Beads HEK293
Mouse SORD-8575M Recombinant Mouse SORD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SORD-5671R Recombinant Rat SORD Protein Mammalian Cell His
Rat Sord-7045R Recombinant Rat Sord protein, His & T7-tagged E.coli His/T7 Ala2~Pro357 (Accession # P27867)
Rat SORD-5330R-B Recombinant Rat SORD Protein Pre-coupled Magnetic Beads HEK293
Rat SORD-5330R Recombinant Rat SORD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cattle SORD-7044C Recombinant Cattle SORD protein, His & T7-tagged E.coli His/T7 Ala4~Lys344 (Accession # Q58D31)
Cynomolgus Monkey SORD-958C Recombinant Cynomolgus SORD Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey SORD-701C-B Recombinant Cynomolgus Monkey SORD Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey SORD-701C Recombinant Cynomolgus Monkey SORD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SORD-4408R Recombinant Rhesus monkey SORD Protein, His-tagged Mammalian Cell His
Rhesus Macaque SORD-4224R Recombinant Rhesus Macaque SORD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SORD-4224R-B Recombinant Rhesus Macaque SORD Protein Pre-coupled Magnetic Beads HEK293
Zebrafish SORD-7683Z Recombinant Zebrafish SORD Mammalian Cell His
Chicken SORD-5544C Recombinant Chicken SORD Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SORD Related Articles

SORD involved in several pathways and played different roles in them. We selected most pathways SORD participated on our site, such as Pentose and glucuronate interconversions, Fructose and mannose metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with SORD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pentose and glucuronate interconversionsUGT1A7C;UGT5G1;UGP2;ALDH2.2;AKR1B8;RPE;UGT2B7;AKR1B1;GUSB
Fructose and mannose metabolismMPI;HK2;FBP2;PFKFB3;TPI1B;PMM1;PFKMA;ALDOB;ALDOAA
Metabolic pathwaysFBP1;HPGDS;LALBA;ADC;COX5B;POLR2G;TPH2;STT3B;GALNT10

SORD has several biochemical functions, for example, D-xylulose reductase activity, L-iditol 2-dehydrogenase activity, NAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SORD itself. We selected most functions SORD had, and list some proteins which have the same functions with SORD. You can find most of the proteins on our site.

Function Related Protein
D-xylulose reductase activity
L-iditol 2-dehydrogenase activity
NAD bindingGRHPRA;ADH1;IDH3G;CYB5R3;GPD1;NNT;NDUFV1;AOX1;GPD1C
carbohydrate bindingCLEC2H;KLRC1;GALNT6;KLRA8;KLRB1A;GALNT9;CNTN2;FCN1;KLRD1
identical protein bindingZNF703;PPPDE2;SEPT7;CEP170L;CIDEB;MICU1;HACL1;PUF60;LRRK1
zinc ion bindingMMP11;JADE1;BIRC3;BPTF;CPN1;PHC2;FTR72;AKAP8;MAN2C1

SORD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SORD here. Most of them are supplied by our site. Hope this information will be useful for your research of SORD.

GH1; TNIK; RELA; MYH9; ANLN; PDLIM7; CFAP97

Li, TF; Bourgeois, JP; et al. Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging. FASEB JOURNAL 26:3969-3979(2012).
  • Q&As
  • Reviews

Q&As (6)

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What diseases are SORD proteins associated with? 09/22/2022

At present, the association between SORD protein and disease is not well understood, and further research is needed to explore its role in specific diseases.

How are SORD proteins related to antioxidants? 06/22/2022

SORD protein is involved in the antioxidant process in cells, and may indirectly affect the antioxidant capacity in cells by regulating heptitol-6-phosphate metabolism.

Are SORD protein mutations associated with genetic disorders? 06/14/2022

There is no clear information on the association between SORD protein mutations and inherited diseases.

Does the loss of function of the SORD protein lead to disease? 09/04/2021

There is no evidence that the lack of SORD protein function directly leads to the development of disease. However, it may affect the normal function of the glucose metabolism pathway.

How is SORD protein related to metabolic diseases? 12/07/2020

The protein may play a role in metabolic pathways related to metabolic diseases (e.g., diabetes mellitus and metabolic syndrome), but the specific relationship still needs to be further studied.

What is the function of SORD protein in the human body? 03/03/2020

SORD protein is involved in the heptylol-6-phosphoreductase reaction in the glucose metabolism pathway, which converts heptitol-6-phosphate to cholesterol alcohol.

Customer Reviews (3)

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Reviews
01/12/2023

    The stability of SORD products allows them to cope with different experimental conditions and modes of operation.

    12/03/2021

      SORD has a high specific activity and can exert strong biological effects at low concentrations.

      07/05/2021

        When experiments were performed with SORD, the reproducibility of the results was excellent.

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