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SOX2

  • Official Full Name

    SRY (sex determining region Y)-box 2

  • Overview

    This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]
  • Synonyms

    SOX2; SRY (sex determining region Y)-box 2; ANOP3; MCOPS3; transcription factor SOX-2; transcription factor SOX2; SRY-related HMG-box gene 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • MBP
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SOX2-67H Active Recombinant Human SOX2 protein E.coli N/A
Human SOX2-667H Recombinant Human SOX2, His-tagged E.coli His
Human SOX2-3629H Recombinant Human SOX2 E.coli N/A
Human SOX2-2049H Recombinant Human SRY (Sex Determining Region Y)-Box 2, His-tagged E.coli His
Human SOX2-608H Recombinant Human SOX2 Protein, His-tagged E.coli His His105~Met317
Human SOX2-562H Recombinant Human SOX2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SOX2-1561HCL Recombinant Human SOX2 293 Cell Lysate HEK293 N/A
Human SOX2-2076H Recombinant Human SOX2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SOX2-3519H Recombinant Human SOX2 protein, His-SUMO-tagged E.coli His-SUMO 1-317aa
Human SOX2-1613HFL Recombinant Full Length Human SOX2 Protein, C-Flag-tagged Mammalian cells Flag
Human SOX2-837H Recombinant Human SOX2 protein E.coli N/A 330
Human SOX2-2076H-B Recombinant Human SOX2 Protein Pre-coupled Magnetic Beads HEK293
Human SOX2-1274H Recombinant Human SOX2 Protein (R40-D123), Tag Free E.coli No tag R40-D123
Human SOX2-3881H Recombinant Human SOX2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SOX2-2771H Recombinant Human SOX2 protein(11-90 aa), C-His-tagged E. coli C-His 11-90 aa
Human SOX2-30150H Recombinant Human SOX2 protein, GST-tagged E.coli GST Met59-Thr118
Human SOX2-2772H Recombinant Human SOX2 protein(121-310 aa), N-MBP & C-His-tagged HEK293 N-MBP & C-His 121-310 aa
Human SOX2-3962HFL Recombinant Full Length Human SOX2 protein, Flag-tagged Mamanlian cells Flag
Human SOX2-1379H Recombinant Human SOX2 protein, His-tagged E.coli His 1-317aa((M317MC)
Mouse Sox2-193M Recombinant Mouse Sox2, His-tagged E.coli His
Mouse SOX2-15780M Recombinant Mouse SOX2 Protein Mammalian Cell His
Mouse SOX2-8590M Recombinant Mouse SOX2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SOX2-8590M-B Recombinant Mouse SOX2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Sox2-6054M Recombinant Mouse Sox2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque SOX2-4413R Recombinant Rhesus monkey SOX2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SOX2-4229R Recombinant Rhesus Macaque SOX2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SOX2-4229R-B Recombinant Rhesus Macaque SOX2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish SOX2-12337Z Recombinant Zebrafish SOX2 Mammalian Cell His
Chicken SOX2-6743C Recombinant Chicken SOX2 Mammalian Cell His
Kit-2289 SOX2 (Human) Transcription Factor Activity Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SOX2 Related Articles

SOX2 involved in several pathways and played different roles in them. We selected most pathways SOX2 participated on our site, such as Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hippo signaling pathwayYWHAE;FZD9;PPP2CB;BTRC;PPP1CC;PRKCI;INADL;LATS1;TGFBR1
Signaling pathways regulating pluripotency of stem cellsPIK3R5;POU5F1;PIK3R3;WNT9B;HESX1;MAP2K1;LHX5;FZD8;BMPR1A

SOX2 has several biochemical functions, for example, DNA binding, miRNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOX2 itself. We selected most functions SOX2 had, and list some proteins which have the same functions with SOX2. You can find most of the proteins on our site.

Function Related Protein
DNA bindingCTC1;ZFP639;ZKSCAN5;PNN;AHRRA;KRBA2;NR5A2;ASCL1A;DNAJC2
miRNA bindingLIN28A;MEF2C;TRIM71;RBM4;AGO1;POU5F1;PNPT1;DICER1;SOX2
protein bindingPACS1;NRIP3;DAXX;SELPLG;MID2;PICK1;RASA1;ORAI3;PRDM1
sequence-specific DNA bindingCLOCK;ASCL1A;ZKSCAN1;SOX21B;SPDEF;HSFY1;MTPN;ZFP423;PAX6B
transcription factor activity, sequence-specific DNA bindingPKNOX1;RHOXF1;TEAD1;SALL4;HDAC1;TLX2;ZIK1;JUNBB;FOXN2B
transcription regulatory region DNA bindingATMIN;FOXI1;NFKB1;TCF7L2;TAF9;WNT11;HIVEP2;RBBP5;AHR
transcription regulatory region sequence-specific DNA bindingMEF2AA;TFAP2A;NFE2L3;SIN3A;POU5F1;NFE2L1;NFE2L2A;FOXJ1;ATF3
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingONECUT1;WT1;GLI2;TFE3B;EHF;HLTF;MITF;FOXJ2;ATF2

SOX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOX2.

SUMO1; PRKCI; POU5F1; SALL2; CASP8; hhat_human_gene; gli2_human_gene; jag1_human_gene; gli3_human_gene; mycn_human_gene; necd_human_gene

Tyagi, D; Perez, JB; et al. Detection of embryonic stem cell lysate biomarkers by surface plasmon resonance with reduced nonspecific adsorption. ANALYTICAL BIOCHEMISTRY 471:29-37(2015).
Ginisty, A; Gely-Pernot, A; et al. Evidence for a Subventricular Zone Neural Stem Cell Phagocytic Activity Stimulated by the Vitamin K-Dependent Factor Protein S. STEM CELLS 33:515-525(2015).
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