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SOX6

Official Full Name

SRY (sex determining region Y)-box 6
Overview

This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Synonyms

SOX6; SRY (sex determining region Y)-box 6; SOXD; HSSOX6; transcription factor SOX-6; SRY-box containing gene 6;

Type

Cell & Tissue Lysates
Recombinant Proteins

Species

Human
Mouse
Rat
Zebrafish

Source

E. coli
E.coli
HEK293
HEK293T
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SOX6-1557HCL	Recombinant Human SOX6 293 Cell Lysate	HEK293	N/A		Inquiry
Human	SOX6-5407H	Recombinant Human SOX6 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	SOX6-5078H	Recombinant Human SOX6 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	SOX6-2721H	Recombinant Human SOX6 Protein, His-tagged	E.coli	N-His	Met1-Pro269	Inquiry
Human	SOX6-2740H	Recombinant Human SOX6 protein(21-260 aa), C-His-tagged	E. coli	C-His	21-260 aa	Inquiry
Human	SOX6-3555H	Recombinant Human SOX6 protein, His-tagged	E.coli	His	272-828 aa	$319 / 25ug
Mouse	Sox6-6058M	Recombinant Mouse Sox6 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rat	Sox6-2090R	Recombinant Rat Sox6 Protein, His-tagged	E.coli	N-His	Met1-Pro266	Inquiry
Zebrafish	SOX6-6616Z	Recombinant Zebrafish SOX6	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SOX6 Related Articles
SOX6 Related Research Area

SOX6 involved in several pathways and played different roles in them. We selected most pathways SOX6 participated on our site, such as Deactivation of the beta-catenin transactivating complex, Endochondral Ossification, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOX6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Deactivation of the beta-catenin transactivating complex	PYGO2;TLE3;TLE4;ASH2L;TLE2;RBBP5;SOX32;BCL9;TLE1
Endochondral Ossification	MMP13;KIF3A;MGP;FRZB;RUNX2A;CTSL2;RUNX3;CDKN1C;PTH
Signal Transduction	ARHGAP29B;PDK2;EVC;MLN;UTS2D;ANXA1A;OBSCN;DHRS3A;ARHGEF18A
Signaling by Wnt	FAM123B;KREMEN1;RSPO4;WNT8-2;SOX9B;LEO1;C;AES;KLHL12
TCF dependent signaling in response to WNT	RNF146;SRY;RBBP5;C;LGR5;TNKS2;SOX6;PYGO1;RSPO1

SOX6 has several biochemical functions, for example, DNA binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOX6 itself. We selected most functions SOX6 had, and list some proteins which have the same functions with SOX6. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	NKX2.2A;ONECUTL;INSM1A;ABL1;MUS81;DBX1;REV3L;AHR1A;AHR2
protein binding	CHP;YWHAH;PKD2L1;TMUB2;LRP5;NOL6;C4orf19;ETF1;WDYHV1
protein heterodimerization activity	SUPT5H;UGT1A6B;TAF11;ENO2;SIM2;BCL2L2;OSTA;DMRTA2;HIST1H4E
sequence-specific DNA binding	RBPJ;LHX1A;CREMB;ARNTL;CHES1;VDRB;ATF4B2;ENG2B;NKX2-6
transcription factor activity, sequence-specific DNA binding	TCF4;RFX1A;HOXB2A;TRPS1;ZNF131;GPBP1L1;NOTCH1;CEBPD;NR3C2
transcription regulatory region DNA binding	HIVEP2A;CALCOCO1;ZFP161;HIVEP3;KCNA3;CDK5RAP2;SMAD4;TRP53;HNRNPL

SOX6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOX6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOX6.

SHOX; POMGNT1; ZNF184

Rudrabhatla, P; Utreras, E; et al. Regulation of Sox6 by Cyclin Dependent Kinase 5 in Brain. PLOS ONE 9:-(2014).

Amano, K; Hata, K; et al. Sox9 Family Members Negatively Regulate Maturation and Calcification of Chondrocytes through Up-Regulation of Parathyroid Hormone-related Protein. MOLECULAR BIOLOGY OF THE CELL 20:4541-4551(2009).

Chondrogenesis Markers

Neural Stem Cell Transcription Factors