SP3
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Official Full Name
Sp3 transcription factor
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Overview
The sequence-specific transcription factor Sp3 binds GC and GT box sequences in the promoters of a variety of genes. The Sp3 transcription factor contains three zinc finger domains that determine sequence specificity of DNA binding. This transcription fac -
Synonyms
SP3; Sp3 transcription factor; transcription factor Sp3; SPR 2; specificity protein 3; GC-binding transcription factor Sp3; SPR2; DKFZp686O1631;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- SL2
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- SP3 Related Articles
SP3 involved in several pathways and played different roles in them. We selected most pathways SP3 participated on our site, such as Regulation of Telomerase, SIDS Susceptibility Pathways, Selenium Metabolism and Selenoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with SP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of Telomerase | TNKS;PINX1;MXD1;DKC1;NR2F2;SP3;CMTM2A |
| SIDS Susceptibility Pathways | PLP1;PHOX2B;TPPP;IL1RN;LMX1B;YBX1;CC2D1A;PKNOX1;CDCA7L |
| Selenium Metabolism and Selenoproteins | CREM;TXNRD3IT1;SELT;MSRB1;SELK;TXNRD2;SELENBP1;TRNAU1AP;FBXO17 |
SP3 has several biochemical functions, for example, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SP3 itself. We selected most functions SP3 had, and list some proteins which have the same functions with SP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter sequence-specific DNA binding | H3F3B;STAT5A;ZNF335;TRP53;SMAD5;TP53;PAX6;SP3;EGR1 |
| RNA polymerase II regulatory region sequence-specific DNA binding | E2F7;TFAP2C;IKZF3;NME2;FOXK1;ETV3;ZNF79;MNT;SNAI1 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXN2B;FOXO1B;BMPR1A;LYL1;HIF1AB;FOXO4;SPI1;ZNF131;HIF1AL2 |
| chromatin binding | RNF168;PHF13;HMGB2;BAHD1;SP140L;ANKRD2;TFAM;SOX10;TOX |
| core promoter proximal region sequence-specific DNA binding | ZFP516;TFAP2A;DMRT2;DMRTA1;SMAD3;DMRT2A;SP3;CREBBP;PAX2 |
| metal ion binding | GFI1AB;ZNF865;MOCS3;DUS3L;SMG6;MTMR4;CYGB2;ENO2;ATP2B4 |
| protein binding | KIF23;SAP18;CASK;DHX16;CDON;FANCG;OSTB;NOL3;ABT1 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | ASCL2;HINFP;NKX3-2;AEBP2;ZBTB20;POU4F2;HOXA2;NR2E1;ZFPM2 |
SP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SP3.
ESR1; GABPA; gc_box_foxp3_promoter_probe; prkra_human_gene; GCH1; HTT; STK19; q5nig6_fratt; dnaC_26; yfkA; mdm2_human_probe; bmf_human_gene
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