SPAG8
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Official Full Name
sperm associated antigen 8
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Overview
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined. -
Synonyms
SPAG8; sperm associated antigen 8; sperm-associated antigen 8; BS 84; HSD 1; hSMP 1; SPAG3; MGC26201; OTTHUMP00000021352; HSD1; hSMP1; MH SPAG8; OTTMUSP00000032209; SMP1; Sperm associated antigen 8 like protein; Sperm membrane protein 1; OTTHUMP00000215542; OTTHUMP00000215543; OTTHUMP00000215544; OTTHUMP00000215545; sperm membrane protein BS-84; BS-84; HSD-1; hSMP-1;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | SPAG8-2895H | Recombinant Human SPAG8, His-tagged | E.coli | His | N-term-301aa | |
| Human | SPAG8-1547HCL | Recombinant Human SPAG8 293 Cell Lysate | HEK293 | N/A |
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- Involved Pathway
- Protein Function
- Interacting Protein
SPAG8 involved in several pathways and played different roles in them. We selected most pathways SPAG8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SPAG8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
SPAG8 has several biochemical functions, for example, microtubule binding, molecular_function, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPAG8 itself. We selected most functions SPAG8 had, and list some proteins which have the same functions with SPAG8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| microtubule binding | S100A9;SKA1;SBDS;KIF15;GOLSYN;CEP57;PRNP;WHAMM;KIF21A |
| molecular_function | C2orf28;FAM13B;FAM92A1;TMEM222A;VMN1R165;IGLON5;SCAND2P;UBL5;PSTPIP1B |
| protein binding | PMP22;DAXX;CCL18;DSC2;DZIP1;GJA1;UBE2V2;TGFA;RAB6A |
SPAG8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPAG8 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPAG8.
CSTF2; SNRPC; KLHL32; DTX2; PRMT5; PRMT2; KDM3B; CARM1; PRMT1; WHSC1L1; JMJD4; UBQLN4
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