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SPARC

  • Official Full Name

    secreted protein, acidic, cysteine-rich (osteonectin)

  • Overview

    SPARC, an acronym for “secreted protein, acidic and rich in cysteine”, is also known as osteonectin or BM-40. It is the founding member of a family of secreted matricellular proteins with similar domain structure. The 303 amino acid, 43 kDa protein contains a 17 aa signal sequence, an N-terminal acidic region that binds calcium, a follistatin domain containing Kazal-like sequences, and a C-terminal extracellular calcium (EC) binding domain with two EF-hand motifs . SPARC is produced by fibroblasts, capillary endothelial cells, platelets and macrophages,especially in areas of tissue morphogenesis and remodeling. SPARC shows context-specific effects, but generally inhibits adhesion, spreading and proliferation, and promotes collagen matrix formation. For endothelial cells,SPARC disrupts focal adhesions and binds and sequesters PDGF and VEGF. SPARC is abundantly expressed in bone, where it promotes osteoblast differentiation and inhibits adipogenesis.
  • Synonyms

    ON; BM-40; Osteonectin; Basement-membrane protein 40; Osteonectin (secreted protein, acidic, cysteine-rich); SPARC precursor; Secreted protein acidic and rich in cysteine; cysteine-rich protein; secreted protein, acidic, cysteine-rich (osteonectin); SPRC_HUMAN; SPARC [Precursor]; SPARC;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Rabbit
  • Rat
  • Zebrafish
  • Bone
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Insect cells
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • MBP
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SPARC-525H Active Recombinant Human SPARC Protein, His-tagged Mammalian cells His Ala18-Ile303
Human SPARC-126H Active Recombinant Human SPARC, His-tagged Mammalian cells His
Human SPARC-2899H Recombinant Human SPARC, GST-tagged E.coli GST 1-303aa
Human SPARC-31437TH Recombinant Human SPARC CHO N/A 286 amino acids
Human SPARC-30654TH Recombinant Human SPARC, MBP-tagged E.coli MBP
Human SPARC-3193H Active Recombinant Human SPARC protein, His-tagged HEK293 His Met1-Ile303
Human SPARC-210H Recombinant Human SPARC, His-tagged E.coli His
Human SPARC-11H Recombinant Human SPARC E.coli N/A
Human SPARC-30655TH Recombinant Human SPARC, T7 -tagged E.coli T7
Human SPARC-34H Recombinant Human SPARC protein, MBP-tagged E.coli MBP 1-303 aa (full-length)
Human SPARC-2616HCL Recombinant Human SPARC cell lysate Human Cell N/A
Human SPARC-01H Recombinant Human SPARC Protein, His-Tagged Insect Cell His 295aa
Human SPARC-6342H Recombinant Human SPARC Protein (Ala18-Ile303), C-His tagged Mammalian cells C-His Ala18-Ile303
Human SPARC-2503H Recombinant Human SPARC Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SPARC-103H Recombinant Human SPARC protein E.coli N/A 286
Human SPARC-001H Recombinant Human SPARC Protein, MBP-tagged E.coli MBP 1-303
Human SPARC-5254H Recombinant Human SPARC protein, GST-tagged E.coli GST 18-303aa
Human SPARC-102H Recombinant Human SPARC protein, His-tagged E.coli His 314
Human SPARC-4111H Recombinant Human SPARC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SPARC-6051H Recombinant Human SPARC Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SPARC-30653TH Native Human SPARC N/A
Human SPARC-2725H Recombinant Human SPARC Protein, His-tagged CHO N-His Ala18-Ile303
Human SPARC-6343H Recombinant Human SPARC Protein (Ala18-Ile303), N-His tagged E.coli N-His Ala18-Ile303
Human SPARC-4111H-B Recombinant Human SPARC Protein Pre-coupled Magnetic Beads HEK293
Mouse Sparc-4030M Active Recombinant Mouse Sparc, His-tagged Mammalian cells His
Mouse Sparc-7698M Recombinant Mouse Sparc protein, His-tagged E.coli His Ala18~Ile302 (Accession # P07214)
Mouse Sparc-4034M Active Recombinant Mouse Sparc protein(Met1-Ile302), His-tagged HEK293 C-His Met1-Ile302
Mouse SPARC-2120MCL Recombinant Mouse SPARC cell lysate Human Cell N/A
Mouse Sparc-8608M Recombinant Mouse Sparc Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Sparc-6073M Recombinant Mouse Sparc Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Sparc-010M Recombinant Mouse Sparc Protein, His-tagged Insect Cells His 18-302aa
Mouse Sparc-034M Recombinant Mouse Sparc Protein, His-tagged Insect cells His
Mouse Sparc-8608M-B Recombinant Mouse Sparc Protein Pre-coupled Magnetic Beads HEK293
Rat SPARC-538R Active Recombinant Rat SPARC Protein, His-tagged HEK293 His Met1-Ile301
Rat SPARC-5683R Recombinant Rat SPARC Protein Mammalian Cell His
Rat Sparc-7699R Recombinant Rat Sparc protein, His-tagged E.coli His Ala18~Ile301 (Accession # P16975)
Rat SPARC-5342R Recombinant Rat SPARC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SPARC-5342R-B Recombinant Rat SPARC Protein Pre-coupled Magnetic Beads HEK293
Rabbit SPARC-7700R Recombinant Rabbit SPARC protein, His & T7-tagged E.coli His/T7 Ala18~Glu273 (Accession # P36233)
Bovine SPARC-287B Native Bovine Osteonectin Bone N/A
Zebrafish SPARC-263Z Recombinant Zebrafish SPARC Mammalian Cell His
Chicken SPARC-5980C Recombinant Chicken SPARC Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SPARC Related Articles
  • SPARC Related Research Area

SPARC involved in several pathways and played different roles in them. We selected most pathways SPARC participated on our site, such as Binding and Uptake of Ligands by Scavenger Receptors, ECM proteoglycans, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPARC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Binding and Uptake of Ligands by Scavenger ReceptorsSTAB2;IGKV1-5;HP;AMBP;IGLC2;SCGB3A2;LOC479668;SAA1;HYOU1
ECM proteoglycansMATN3;FMOD;ASPN;HAPLN1;MATN3B;VCANB;BGNA;DMP1;DAG1
Extracellular matrix organizationLAMC3;LTBP4;TPSAB1;ADAM8A;COL4A6;KLK7;COL4A5;ELANE;PRP
HemostasisSERPINE2;PROCA;TAE1;RAPGEF4;LRRC16A;CD9A;SIRPA;ATP2B1B;DGKB
Platelet activation, signaling and aggregationAASS;TRPC6A;ABHD6B;CALU;PLEK;GNA13B;IGF2B;C6orf25;CD9B
Platelet degranulationCAP1;CALU;PLEK;WDR1;MMRN1;F13A1B;MMRN2A;SCG3;BRPF3
Response to elevated platelet cytosolic Ca2+F13A1A.1;BRPF3;CD9A;CAP1;MMRN2A;CD9B;HRG;SCG3;STXBP3A
Scavenging by Class H ReceptorsSPARC;STAB2

SPARC has several biochemical functions, for example, calcium ion binding, collagen binding, extracellular matrix binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPARC itself. We selected most functions SPARC had, and list some proteins which have the same functions with SPARC. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingNOTCH4;RGN;PKD2;PCDH2G9;CPNE6;SLIT1A;FBN2B;PCDHB13;FAT1A
collagen bindingPDGFB;ACHE;SMAD4;CD44;PAK1;CTSK;GPR56;SMAD3;Itga10&Itgb1
extracellular matrix bindingVTN;GPR56;ITGB3;SID4;DMP1;CD248;VEGFA;SPP1;ITGAV
protein bindingSLC30A1;PTPN22;UHRF2;SYNM;PTPRS;FAM20C;NTN4;SOCS3;FDXR

SPARC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPARC here. Most of them are supplied by our site. Hope this information will be useful for your research of SPARC.

faf; XRCC6; fusA; ZNF579

Onoz, M; Basaran, R; et al. Correlation between SPARC (Osteonectin) expression with immunophenotypical and invasion characteristics of pituitary adenomas. APMIS 123:199-204(2015).
Peixoto, E; Atorrasagasti, C; et al. SPARC (secreted protein acidic and rich in cysteine) knockdown protects mice from acute liver injury by reducing vascular endothelial cell damage. GENE THERAPY 22:9-19(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How is the SPARC protein linked to cancer? 04/18/2023

SPARC is associated with cancer progression, as it can influence tumor growth, invasion, and angiogenesis. Its expression levels in tumors are often studied for prognostic and diagnostic purposes.

Can SPARC be a potential therapeutic target for cancer treatment? 12/08/2022

Yes, SPARC is being explored as a therapeutic target for cancer. Researchers are investigating ways to modulate its activity to hinder tumor progression or enhance the efficacy of existing treatments.

In what ways can SPARC expression be detected and measured in clinical settings? 04/25/2021

SPARC expression can be detected through techniques like immunohistochemistry, Western blotting, and molecular assays. These methods help assess SPARC levels in tissues or blood samples.

How does SPARC contribute to tissue repair and regeneration? 03/04/2021

SPARC plays a role in tissue repair by influencing cell-matrix interactions and modulating the extracellular environment. Its involvement in wound healing and tissue regeneration makes it a subject of interest in regenerative medicine.

Are there any ongoing clinical trials targeting SPARC for therapeutic interventions? 03/28/2019

Yes, there are clinical trials exploring the potential of targeting SPARC in various diseases, including cancer. These trials aim to evaluate the safety and efficacy of SPARC-modulating agents.

Customer Reviews (3)

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Reviews
07/18/2021

    The SPARC protein finds great utility in protein electron microscopy structure analysis, consistently delivering exceptional results.

    02/09/2017

      Its remarkable sensitivity and specificity make it a valuable tool for accurate and robust data analysis, bolstering the credibility of research outcomes.

      07/10/2016

        Notably, it exhibits exceptional performance in ELISA assays, providing reliable and precise results in the detection and quantification of target molecules.

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