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SPG7

Official Full Name

spastic paraplegia 7 (pure and complicated autosomal recessive)
Overview

This gene encodes a nuclear-encoded mitochondrial metalloprotease protein that is a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 7.
Synonyms

SPG7; spastic paraplegia 7 (pure and complicated autosomal recessive); cell matrix adhesion regulator , CMAR; paraplegin; CAR; SPG5C; Cell adhesion regulator; Cell matrix adhesion regulator; CMAR; PGN; Spastic paraplegia 7 homolog (human); Spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive); Spastic paraplegia protein 7; SPG7 gene; paraplegin, isoform 1; spastic paraplegia 7 protein;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Homo sapiens (Human)
Human
Mouse
Mus musculus (Mouse)
Rat
Rattus norvegicus (Rat)

Source

E.coli
E.coli expression system
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SPG7-30666TH	Recombinant Human SPG7 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	SPG7-1518HCL	Recombinant Human SPG7 293 Cell Lysate	HEK293	N/A		Inquiry
Human	SPG7-490HF	Recombinant Full Length Human SPG7 Protein, GST-tagged	In Vitro Cell Free System	GST		Inquiry
Human	SPG7-2841H	Recombinant Human SPG7 protein, His-tagged	E.coli	His	362-406 aa	$319 / 25ug
Mouse	SPG7-15876M	Recombinant Mouse SPG7 Protein	Mammalian Cell	His		Inquiry
Mouse	SPG7-8641M	Recombinant Mouse SPG7 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	SPG7-8641M-B	Recombinant Mouse SPG7 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	SPG7-5704R	Recombinant Rat SPG7 Protein	Mammalian Cell	His		Inquiry
Rat	SPG7-5363R	Recombinant Rat SPG7 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	SPG7-5363R-B	Recombinant Rat SPG7 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Homo sapiens (Human)	RFL4198HF	Recombinant Full Length Human Paraplegin(Spg7) Protein, His-Tagged	E.coli expression system	His	Full Length (1-795)	Inquiry
Mus musculus (Mouse)	RFL20563MF	Recombinant Full Length Mouse Paraplegin(Spg7) Protein, His-Tagged	E.coli expression system	His	Full Length (1-781)	Inquiry
Rattus norvegicus (Rat)	RFL16878RF	Recombinant Full Length Rat Paraplegin(Spg7) Protein, His-Tagged	E.coli expression system	His	Full Length (1-744)	Inquiry
Chicken	SPG7-1902C	Recombinant Chicken SPG7	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SPG7 Related Articles

SPG7 involved in several pathways and played different roles in them. We selected most pathways SPG7 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SPG7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

SPG7 has several biochemical functions, for example, ATP binding, ATP-dependent peptidase activity, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SPG7 itself. We selected most functions SPG7 had, and list some proteins which have the same functions with SPG7. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	CAMK1DA;MAPKAPK2A;SLK;P2RX7;DDX55;HIPK3B;STK25B;SMARCAL1;HSPA4A
ATP-dependent peptidase activity	LONP1;LONRF1L;YME1L1;SPG7;LONRF3;CRBN;AFG3L2;LONRF2
metalloendopeptidase activity	MEP1A.2;PAPPAA;MMP1A;MMP11;BMP1;AFG3L2;MEP1B;ADAMTSL5;ADAM10B
peptidase activity	SPPL3;APH1C;MCPT2;SPG7;MMP14B;FAM108A1;CTSM;METAP2A;ZMPSTE24
protein binding	CD81;GGA3;SDHA;PODXL;APOD;NHLRC2;LEPR;DNM2;RNF111
unfolded protein binding	DNAJB1;PFDN1;AIP;CCT6A;ERLEC1;CHAF1A;GRPEL2;TUBB4B;HSP104
zinc ion binding	PHF11;XIAP;TRIM72;PRDM4;MMP23BB;BMP1;KDM5C;ZCCHC11;SYVN1

SPG7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPG7 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPG7.

MTUS2; PNMA1; MDFI; PSTPIP1; CCNDBP1

Blumkin, L; Lerman-Sagie, T; et al. A new locus (SPG47) maps to 1p13.2-1p12 in an Arabic family with complicated autosomal recessive hereditary spastic paraplegia and thin corpus callosum. JOURNAL OF THE NEUROLOGICAL SCIENCES 305:67-70(2011).

Deeken, JF; Cormier, T; et al. A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform. PHARMACOGENOMICS JOURNAL 10:191-199(2010).