SPRY2
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Official Full Name
sprouty homolog 2 (Drosophila)
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Overview
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008] -
Synonyms
SPRY2; sprouty homolog 2 (Drosophila); hSPRY2; protein sprouty homolog 2; spry-2; sprouty 2;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | SPRY2-1490HCL | Recombinant Human SPRY2 293 Cell Lysate | HEK293 | N/A | ||
Human | SPRY2-1714HFL | Recombinant Full Length Human SPRY2 Protein, C-Flag-tagged | Mammalian cells | Flag | ||
Human | SPRY2-3538H | Recombinant Human SPRY2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | SPRY2-1797H | Recombinant Human SPRY2 protein, His & T7-tagged | E.coli | His/T7 | Ser116~Thr305 (Accession # O43597) | |
Human | SPRY2-2091H | Recombinant Human SPRY2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | SPRY2-2091H-B | Recombinant Human SPRY2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | SPRY2-5523H | Recombinant Human SPRY2 Protein (Ser116-Thr305), N-His tagged | E.coli | N-His | Ser116-Thr305 | |
Mouse | Spry2-1798M | Recombinant Mouse Spry2 protein, His & T7-tagged | E.coli | His/T7 | Gly116~Thr305 (Accession # Q9QXV8) | |
Mouse | Spry2-6110M | Recombinant Mouse Spry2 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Rat | Spry2-1799R | Recombinant Rat Spry2 protein, His & T7-tagged | E.coli | His/T7 | Gly116~Thr304 (Accession # Q5HZA2) | |
Zebrafish | SPRY2-1131Z | Recombinant Zebrafish SPRY2 | Mammalian Cell | His | ||
Chicken | SPRY2-6363C | Recombinant Chicken SPRY2 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- SPRY2 Related Articles
- SPRY2 Related Research Area
SPRY2 involved in several pathways and played different roles in them. We selected most pathways SPRY2 participated on our site, such as EGFR downregulation, EGFR1 Signaling Pathway, FGF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPRY2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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EGFR downregulation | STAM2;AP2M1;AP2S1;AP2A2;AP2B1;SPRY1;AP2A1;PTPRK;SPRY2 |
EGFR1 Signaling Pathway | RALBB;RALBA;SH3BGRL;CRKL;ARF4;ABI1B;MTA2;EEF1A1;PITPNA |
FGF signaling pathway | FGFRL1A;TA;SOX32;EGR2A;SP8A;SP8B;EGR2B;PAK4;JUNBA |
Internalization of ErbB1 | SPRY2;STAMBP;FMNL3;RNF103-CHMP3;ZFYVE28 |
MicroRNAs in cancer | DNMT1;STAT3;CCND2;BCL2;RPS6KA5;SHC1;MDM4;GLS;TGFB2 |
Negative regulation of FGFR1 signaling | |
Negative regulation of FGFR2 signaling | |
Negative regulation of FGFR3 signaling |
SPRY2 has several biochemical functions, for example, protein binding, protein kinase binding, protein serine/threonine kinase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SPRY2 itself. We selected most functions SPRY2 had, and list some proteins which have the same functions with SPRY2. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | NOD1;TBXA2R;PTGER4;HOMER3;PSMB3;PPP3CA;C11orf67;MBNL3;CD200R3 |
protein kinase binding | PTPRK;SPDYA;MAPK4;CCND1;CCNA2;BORA;GYS1;CCNB1;H2AFY |
protein serine/threonine kinase activator activity | STK4;STRADA;MAP2K1;CALM3;IGF2;CALM2;STK3;LTF;ALS2 |
protein serine/threonine kinase inhibitor activity | SPRED1;SPRY2;CIB1;SPRED2;H2AFY |
SPRY2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPRY2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPRY2.
CBL; OTX1
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