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SPRY4

Official Full Name

sprouty homolog 4
Overview

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is;positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et;al., 2002 (PubMed 12027893)).
Synonyms

SPRY4; sprouty homolog 4 (Drosophila); protein sprouty homolog 4; spry-4;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SPRY4-2939H	Recombinant Human SPRY4, His-tagged	E.coli	His	1-165aa	$319 / 25ug
Human	SPRY4-2326H	Recombinant Human SPRY4 protein, His-tagged	E.coli	His		Inquiry
Mouse	SPRY4-15946M	Recombinant Mouse SPRY4 Protein	Mammalian Cell	His		Inquiry
Mouse	SPRY4-8690M-B	Recombinant Mouse SPRY4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	SPRY4-8690M	Recombinant Mouse SPRY4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	SPRY4-9335Z	Recombinant Zebrafish SPRY4	Mammalian Cell	His		Inquiry
Chicken	SPRY4-3568C	Recombinant Chicken SPRY4	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SPRY4 Related Articles

SPRY4 involved in several pathways and played different roles in them. We selected most pathways SPRY4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SPRY4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

SPRY4 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPRY4 itself. We selected most functions SPRY4 had, and list some proteins which have the same functions with SPRY4. You can find most of the proteins on our site.

Function	Related Protein
protein binding	KLF2;SH2D2A;JUB;SLC2A4;PMM2;JMJD7;POLI;VASN;PINX1

SPRY4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPRY4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPRY4.

CBL; TESK1; ZDHHC17; TNS2; RIN3

Gromova, P; Ralea, S; et al. Kit K641E oncogene up-regulates Sprouty homolog 4 and Trophoblast glycoprotein in interstitial cells of Cajal in a murine model of gastrointestinal stromal tumours. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 13:1536-1548(2009).