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SPTB

  • Official Full Name

    spectrin, beta, erythrocytic

  • Overview

    This locus encodes a member of the spectrin gene family. Spectrin proteins, along with ankyrin, play a role in cell membrane organization and stability. The protein encoded by this locus functions in stability of erythrocyte membranes, and mutations in this gene have been associated with spherocytosis type 2, hereditary elliptocytosis, and neonatal hemolytic anemia. Alternatively spliced transcript variants have been described.
  • Synonyms

    SPTB; spectrin, beta, erythrocytic; spectrin beta chain, erythrocyte; spherocytosis; clinical type I; beta-I spectrin; membrane cytoskeletal protein; EL3; HS2; SPH2; HSPTB1;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SPTB-2659H Recombinant Human SPTB protein, His-tagged E.coli His 1800-1900 aa
Dictyostelium discoideum (Slime mold) RFL3260DF Recombinant Full Length Dictyostelium Discoideum Serine Palmitoyltransferase 2(Sptb) Protein, His-Tagged E.coli expression system His Full Length (1-490)
Zebrafish SPTB-9074Z Recombinant Zebrafish SPTB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

SPTB involved in several pathways and played different roles in them. We selected most pathways SPTB participated on our site, such as ARMS-mediated activation, Axon guidance, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPTB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ARMS-mediated activationFRS3;PSMD10;DAB2IPB;CSK;SPTBN2;MARK3;NTF7;NRG4;PSMD9
Axon guidanceGNAI3;PLXNB2;DPYSL2B;GFRA1;DUSP6;AKAP9;ACTR2;AP2M1;HBEGF
Cytokine Signaling in Immune systemPTPRA;IFITM3;IFIT14;IFIT12;IFI30;NOD1;MAP3K8;CASPB;TRIM10
DAP12 interactionsAGO3;DUSP4;DUSP10;LAMTOR2;CSF2RA;FGFR1B;SPRED2;TREM1;ADRBK1
DAP12 signalingSPRED1;NRG2A;CSF2RA;FGFR1B;DUSP1;PHB;MOV10;DUSP7;GRAP2B
Developmental BiologyCOL6A3;CDON;EPHB4B;KALRN;KALRNB;NR5A1;SCN4A;DUSP4;DUSP1
Downstream signal transductionWDR83;PHB;FRS3;SPRED3;PAQR3A;DUSP7;FGF18B;FGF10B;DUSP10
Downstream signaling of activated FGFR1SPRED2;PAQR3B;SPTA1;SPTB;CNKSR1;KBTBD7;RASGEF1A;DUSP2;WDR83

SPTB has several biochemical functions, for example, actin binding, phospholipid binding, structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by SPTB itself. We selected most functions SPTB had, and list some proteins which have the same functions with SPTB. You can find most of the proteins on our site.

Function Related Protein
actin bindingHCLS1;FLNC;MYO3B;TWF1B;TWF1A;PPP1R9B;DBNLA;FHOD3;TMOD3
phospholipid bindingNUP35;SEC14L2;SMURF1;PLEKHA3;SYTL4;F3;PICALMA;PTAFR;BIN2
structural constituent of cytoskeletonSORBS3;TUBGCP3;KRT71;TUBA4L;KRT14;NEFL;ACTA1;TUBA8L2;BICD1

SPTB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPTB here. Most of them are supplied by our site. Hope this information will be useful for your research of SPTB.

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