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SPTBN1

Official Full Name

spectrin, beta, non-erythrocytic 1
Overview

Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

SPTBN1; spectrin, beta, non-erythrocytic 1; spectrin beta chain, brain 1; beta-fodrin; beta-G spectrin; beta-spectrin 2; beta-II spectrin; beta-spectrin II; fodrin beta chain; embryonic liver beta-fodrin; spectrin, non-erythroid beta chain 1; ELF; SPTB2;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rhesus Macaque

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc|DDK

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	SPTBN1-30885TH	Recombinant Human SPTBN1, His-tagged	E.coli	His	Inquiry
Human	SPTBN1-200HCL	Recombinant Human SPTBN1 cell lysate, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry
Rhesus Macaque	SPTBN1-4456R	Recombinant Rhesus monkey SPTBN1 Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	SPTBN1-4272R	Recombinant Rhesus Macaque SPTBN1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rhesus Macaque	SPTBN1-4272R-B	Recombinant Rhesus Macaque SPTBN1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Chicken	SPTBN1-4298C	Recombinant Chicken SPTBN1	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
SPTBN1 Related Articles

SPTBN1 involved in several pathways and played different roles in them. We selected most pathways SPTBN1 participated on our site, such as ARMS-mediated activation, Axon guidance, Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPTBN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
ARMS-mediated activation	JAK1;PSMA8;EGFR;IL17RD;RASGRP4;SPNA2;SPNA1;DUSP2;FRS2B
Axon guidance	NFATC2;FYN;SEMA7A;RHOB;FGFR1B;SLIT2;EPHB4A;DUSP6;JAK1
Cell-Cell communication	CDH8;CDH6;PVRL1A;CLDN20;CDH12;CLDN7;INADL;CDH3;CDH7
Cytokine Signaling in Immune system	JAK1;GBP5;IFIT8;EIF4G1;KBTBD7;FGF10B;DPF1;EIF4G2;MARK3
DAP12 interactions	SPRED2;FGF8B;DUSP2;PTPRA;AGO3;HBEGF;DUSP10;NRG3;DUSP4
DAP12 signaling	SPTBN1;FRS2;IL17RD;PAQR3B;THEM4;SPRED2;GRAP2B;KLB;FRS2A
Developmental Biology	RHOGA;EZRA;SPRED3;FRS3;MYOD1;CAP1;DUSP6;RHOAE;CDON
Downstream signal transduction	AGO1;DUSP9;SPTB;SPRED2;PEA15A;SPRED1;AGO3;DAB2IPB;WDR83

SPTBN1 has several biochemical functions, for example, GTPase binding, actin binding, ankyrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPTBN1 itself. We selected most functions SPTBN1 had, and list some proteins which have the same functions with SPTBN1. You can find most of the proteins on our site.

Function	Related Protein
GTPase binding	VPS41;GM5506;GNB2;RASA1;IARS;SPTBN1;AIMP1;YBX1;GNB3
actin binding	LCP1;ALDOA;FMNL2;GSNB;FMN2;EZRA;GSN;ABLIM1B;TBC1D21
ankyrin binding	KCTD6;SLC4A1;RHBG;NRCAM;SCN5A;PLEC;ATP1A1;RHCG;FLNC
calmodulin binding	MYO5B;MARCKSB;MYH1E;PPP3CC;TRPC2;PDE1A;PCP4;KCNH5;MYO5C
phospholipid binding	SEC14L2;PSD4;NR5A2;F3;SGIP1;NBEAL2;Defa4;LRBA;SYT14
poly(A) RNA binding	MBNL1;PCSK9;NCL;MOV10;PIGC;SUPT6H;CD3EAP;NHP2;H1F0
protein binding	DAPK1;Anks6;SPOPL;RRAGC;PIAS3;CENPJ;ANO6;IKBKB;ZP3
structural constituent of cytoskeleton	TUBD1;KRT6B;LOR;GFAP;ACTL7A;TNNT2A;TUBA3C;TUBA1C;BFSP1

SPTBN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPTBN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPTBN1.

SPTA1; GRB2; CDC5L; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; spectrin_a1_a2_prot; SPTAN1

Lin, L; Yao, ZX; et al. Transcriptional regulation of STAT3 by SPTBN1 and SMAD3 in HCC cAMP-response element-binding proteins ATF3 and CREB2. CARCINOGENESIS 35:2393-2403(2014).

Demiralp, DO; Haznedaroglu, IC; et al. Functional proteomic analysis of Ankaferd (R) Blood Stopper. TURKISH JOURNAL OF HEMATOLOGY 27:70-77(2010).