SRF
-
Official Full Name
serum response factor (c-fos serum response element-binding transcription factor)
-
Overview
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). -
Synonyms
SRF; serum response factor (c-fos serum response element-binding transcription factor); serum response factor; MCM1;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- Myc
- DDK
- Flag
- His
- His (Fc)
- Avi
- His|SUMO
- His|T7
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- SRF Related Articles
SRF involved in several pathways and played different roles in them. We selected most pathways SRF participated on our site, such as MAPK signaling pathway, cGMP-PKG signaling pathway, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | MRAS;RAC1A;RPS6KA1;FGF7;PDGFRA;FAS;MAPK8IP2;GADD45BB;MAP4K2 |
| cGMP-PKG signaling pathway | ATP1B1;PIK3R3;ATF4;NFATC2;GNA11;ATP1B3;PRKCE;MEF2C;KCNMB4 |
| HTLV-I infection | TGFB3;CCND1;ITGB2L;LTBR;TLN1;DVL1;MAP3K3;IL2RB;PIK3CB |
| Viral carcinogenesis | HIST1H2BG;PIK3R3;MAPK1;GTF2A1;RB1;TRAF2;BAD;MAPKAPK2;GTF2H2C |
SRF has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin DNA binding, histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SRF itself. We selected most functions SRF had, and list some proteins which have the same functions with SRF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | NKX2-8;ETV4;CREB3;MIXL1;HIST2H3A;MYOG;MYBL1;TFAP4;NFE2L3 |
| chromatin DNA binding | MYOG;PER1;RELA;CLOCK;SLAMF7;FOXC2;INSM1B;MYOD1;HDAC3 |
| histone deacetylase binding | RFXANK;TOP2B;YWHAE;HDAC5;BCOR;PKN2;ZNF703;GMNN;MEF2B |
| primary miRNA binding | DGCR8;SRF |
| protein binding | CBX1;MEN1;AFF4;ANKZF1;PIPOX;RAB18;ITGA7;ZMYM4;TJAP1 |
| protein homodimerization activity | NETO2;CALCOCO2;SMAD3;CTBP2;IDH1;USH1G;HSF2;TERF2;NTRK1 |
| serum response element binding | NKX2;SRF;NKX2-5 |
| contributes_to transcription factor activity, RNA polymerase II core promoter sequence-specific | NKX3-1;SRF |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | SOX10;ZFHX3;PTH;NKX2;T;FOXP3;NR1H4;POU3F1;MEF2A |
| transcription factor activity, RNA polymerase II transcription factor binding | HIF1A;ATF4;GTF2E1;MAMSTR;MYOCD;TWIST2;ZNF296;NACC2;YAP1 |
| transcription factor activity, sequence-specific DNA binding | SMAD6A;MEF2B;DBPB;SPI1B;ZIC2;MYT1LA;DMRTA2;TCF7L1B;ZNF167 |
| transcription factor binding | HDAC2;IFT172;SNF8;NKX2-5;TBP;Ar;HDAC3;RARA;TRIB2 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | KCNA3;PAX8;TP63;TFAP2C;SPI1;NFATC3;ISL1;MYBL2;HNRNPK |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | SOHLH1;PPARG;GABPA;TRP53;GLIS1;SOX17;ATF2;NHLH1;MAFBB |
SRF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRF here. Most of them are supplied by our site. Hope this information will be useful for your research of SRF.
MKL2; MKL1; MYOD1; MYOG; MYOCD; ALDH3A1; CIRBP; q8clf6_yerpe
- Q&As
- Reviews
Q&As (5)
Ask a questionSRF regulates genes involved in tissue development and regeneration, making it important for understanding and promoting tissue repair.
SRF's involvement in regulating genes related to cell proliferation makes it a focus in cancer research, with efforts to understand and target its activity to control tumor growth.
While not a direct diagnostic marker, alterations in SRF activity may serve as indicators in certain diseases, contributing to diagnostic assessments.
As of now, there are no widely used drugs that specifically target SRF protein, but research is ongoing to develop potential therapeutic agents.
Yes, the expression and activity of SRF protein can be altered in various disease states, contributing to the pathology of certain conditions.
Customer Reviews (3)
Write a reviewWhether it's modifying protocols, providing custom formulations, or offering personalized recommendations, their flexibility ensures that I have the necessary tools to carry out my experiments seamlessly.
Their proactive approach ensures that I am always working with the latest advancements in SRF protein research, allowing me to explore new avenues and potentially uncover groundbreaking discoveries.
The combination of exceptional quality, reliable performance, and dedicated customer service makes them an invaluable partner in my research journey.
Ask a Question for All SRF Products
Required fields are marked with *
My Review for All SRF Products
Required fields are marked with *
