SRPK1
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Official Full Name
SRSF protein kinase 1
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Overview
This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined. -
Synonyms
SRPK1; SRSF protein kinase 1; SFRS protein kinase 1; serine/arginine rich splicing factor kinase 1; SFRSK1; SR protein kinase 1; SR-protein-specific kinase 1; serine/threonine-protein kinase SRPK1; serine/arginine-rich splicing factor kinase 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Human
- Mouse
- E. coli
- E.coli
- HEK293
- Insect (sf21)
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
SRPK1 involved in several pathways and played different roles in them. We selected most pathways SRPK1 participated on our site, such as Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Herpes simplex infection | EIF2S1B;IFNA8;IFNA14;CASP3A;C5;SRSF5A;SRSF2B;TAP2;IFNG1-2 |
SRPK1 has several biochemical functions, for example, ATP binding, magnesium ion binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SRPK1 itself. We selected most functions SRPK1 had, and list some proteins which have the same functions with SRPK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ATP2A1;KIF17;PIM3;BCKDK;ATP1A3A;CCT6B;MYLK2;GCLC;MYH1 |
| magnesium ion binding | ARF1;PGM5;RPS6KA6;IDH3B;CDC42BPB;TSSK1;ADPRH;SRR;ENOPH1 |
| poly(A) RNA binding | MRPL3;RPUSD2;SPATS2;RTN4;UCHL5;RC3H2;RRP1;UTP18;MTIF2 |
| protein binding | ZCCHC7;TPRGL;ORC1L;CBX8;SMOC1;KLF10;BOC;FEM1C;CTNNA2 |
| protein kinase activity | EPHA2A;MAP2K4A;PINK1;FASTKD2;cka1;AURKA;KITB;RPS6KB2;BMPR1AB |
| protein serine/threonine kinase activity | STRC;STK4;GRK1B;IRAK3;PRKCZ;CDK12;STK17B;ULK1A;CAMK1DA |
SRPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SRPK1.
SRSF1; RNPS1; a7y3z3_hpv16; TP53; YWHAB; YWHAG; PRPF38A; DGCR8
- Q&As
- Reviews
Q&As (5)
Ask a questionCombination therapy with SRPK1 inhibitors and other cancer treatments, such as chemotherapy or immunotherapy, is being explored for enhanced efficacy.
SRPK1 phosphorylates SR proteins, which affects their splicing activity and can lead to the inclusion or exclusion of specific exons in mRNA transcripts.
SRPK1 dysregulation has been implicated in neurodegenerative diseases, cardiovascular disorders, and autoimmune conditions.
Some genetic variations in the SRPK1 gene have been associated with increased susceptibility to certain diseases, but further research is needed to establish these connections.
SRPK1 abnormalities can lead to errors in RNA splicing, contributing to RNA processing disorders, such as spinal muscular atrophy and myotonic dystrophy.
Customer Reviews (3)
Write a reviewBy using SRPK1 protein, I can gain insights into the underlying molecular processes contributing to amyloidosis, which can ultimately aid in the development of novel therapeutic strategies.
The manufacturer plays a crucial role in supporting my research with their extensive expertise and resources.
This assurance enables me to confidently utilize the SRPK1 protein in my research, knowing that it will consistently deliver reliable and accurate results.
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