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SRSF2

  • Official Full Name

    serine/arginine-rich splicing factor 2

  • Overview

    The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11.
  • Synonyms

    SRSF2; serine/arginine-rich splicing factor 2; SFRS2, splicing factor, arginine/serine rich 2; PR264; SC 35; SC35; SFRS2A; SR splicing factor 2; 35 kDa; arginine/serine-rich 2; Protein PR264; SC-35; SFRS 2; SFRS2; Splicing component 35 kDa; Splicing component; Splicing factor; Splicing factor arginine/serine rich 2; Splicing factor SC35; Splicing speckle; Splicing speckles; SRp30b; SRSF2_HUMAN; splicing component, 35 kDa; splicing factor, arginine/serine-rich 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • Sf21 Insect Cell
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SRSF2-8495H Active Recombinant Human SRSF2, His-tagged Sf21 Insect Cell His
Human SRSF2-31385TH Recombinant Human SRSF2 N/A
Human SRSF2-1401H Recombinant Human SRSF2 protein, His & GST-tagged E.coli His/GST Thr14~Ser221
Human SRSF2-1592HCL Recombinant Human SRSF2 cell lysate N/A
Rat SRSF2-5747R Recombinant Rat SRSF2 Protein Mammalian Cell His
Rat SRSF2-5406R-B Recombinant Rat SRSF2 Protein Pre-coupled Magnetic Beads HEK293
Rat SRSF2-5406R Recombinant Rat SRSF2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SRSF2-4475R Recombinant Rhesus monkey SRSF2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SRSF2-4291R Recombinant Rhesus Macaque SRSF2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SRSF2-4291R-B Recombinant Rhesus Macaque SRSF2 Protein Pre-coupled Magnetic Beads HEK293
Chicken SRSF2-1089C Recombinant Chicken SRSF2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

SRSF2 involved in several pathways and played different roles in them. We selected most pathways SRSF2 participated on our site, such as Spliceosome, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRSF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
SpliceosomeCWC15;BCAS2;HSPA1A;PPIL1;SARNP;DDX39B;SNRPF;PCBP1;SRSF6
Herpes simplex infectionTAF4B;ALYREF;TBK1;POU2F3;GTF2I;TBP;SOCS3;CFP;SRSF1

SRSF2 has several biochemical functions, for example, nucleotide binding, poly(A) RNA binding, pre-mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SRSF2 itself. We selected most functions SRSF2 had, and list some proteins which have the same functions with SRSF2. You can find most of the proteins on our site.

Function Related Protein
nucleotide bindingATP1A1B;RAF1A;SNRKB;MAP4K6;DXO;DAZL;RAB1;DAZ4;ABCG2D
poly(A) RNA bindingMECP2;CD3EAP;CCDC86;FAM50A;OASL;ANXA11;NUSAP1;BCLAF1;DKC1
pre-mRNA bindingPTBP1;RBM22;TARBP2;DDX5;SRSF2
protein bindingFMNL3;SOX6;CCDC120;FUCA2;COQ9;MAGI2;MTA1;TRIM74;STAR
transcription corepressor activityMAP3K10;CIR1;CCAR1;UBP1;BCOR;IRF2BP2;NFIL3;TSG101;PAWR

SRSF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRSF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SRSF2.

CIR1; KAT5; ESR2; SRPK1; Srek1; ESR1; NCL; CSNK2A1; CDK6; AIRE

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