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SSX1

Official Full Name

synovial sarcoma, X breakpoint 1
Overview

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity.
Synonyms

SSX1; synovial sarcoma, X breakpoint 1; protein SSX1; cancer/testis antigen family 5; member 1; CT5.1; X breakpoint 1; Cancer/testis antigen 5.1; Cancer/testis antigen family 5 member 1; MGC150425; MGC5162; sarcoma, synovial, X chromosome related 1; SSRC; SSX1_HUMAN; Synovial sarcoma; cancer/testis antigen family 5, member 1; sarcoma, synovial, X-chromosome-related 1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian cells
Wheat Germ

Tag

C
Myc
DDK
Flag
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SSX1-31171TH	Recombinant Human SSX1	Wheat Germ	N/A	100 amino acids	Inquiry
Human	SSX1-7541H	Recombinant Human SSX1, His-tagged	E.coli	His	1-188aa	Inquiry
Human	SSX1-30141TH	Recombinant Human SSX1	Wheat Germ	N/A	188 amino acids	Inquiry
Human	SSX1-1450HCL	Recombinant Human SSX1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	SSX1-021H	Recombinant Human SSX1 Protein, MYC/DDK-tagged, C13 and N15-labeled	HEK293	C-Myc/DDK		Inquiry
Human	SSX1-499HF	Recombinant Full Length Human SSX1 Protein	In Vitro Cell Free System		188 amino acids	Inquiry
Human	SSX1-2108H	Recombinant Human SSX1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	SSX1-2040HFL	Recombinant Full Length Human SSX1 Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	SSX1-2108H-B	Recombinant Human SSX1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
SSX1 Related Articles

SSX1 involved in several pathways and played different roles in them. We selected most pathways SSX1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SSX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Transcriptional misregulation in cancer	ATM;RXRB;ARNT2;MMP9;CDK14;EYA1;HIST1H3I;MMP3;HOXA9

SSX1 has several biochemical functions, for example, nucleic acid binding, protein binding, transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SSX1 itself. We selected most functions SSX1 had, and list some proteins which have the same functions with SSX1. You can find most of the proteins on our site.

Function	Related Protein
nucleic acid binding	ZFP12;ZFP319;GFI1AA;GLIS3;ZBTB2B;ZRANB3;GATAD2AB;RBM4.2;PDCD11
protein binding	CNOT2;SETD8;RSPO1;BAD;ATF6;NF1;EPAS1;APOD;VAMP8
transcription corepressor activity	CDYL;SKOR1;RCOR2;MYBBP1A;C1D;NR2F2;NPAT;NAB2;ATF7IP

SSX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SSX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SSX1.

MAGEC2

He, R; Patel, RM; et al. Immunostaining for SYT protein discriminates synovial sarcoma from other soft tissue tumors: analysis of 146 cases. MODERN PATHOLOGY 20:522-528(2007).

Atanackovic, D; Arfsten, J; et al. Cancer-testis antigens are commonly expressed in multiple myeloma and induce systemic immunity following allogeneic stem cell transplantation. BLOOD 109:1103-1112(2007).