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SSX4

Official Full Name

synovial sarcoma, X breakpoint 4
Overview

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4, represents the more telomeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene.
Synonyms

SSX4; synovial sarcoma, X breakpoint 4; protein SSX4; CT5.4; MGC12411; Synovial sarcoma X breakpoint 4; OTTHUMP00000024292; OTTHUMP00000216158; cancer/testis antigen 5.4; SSX4B;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human

Source

E.coli
HEK293
HEK293T
Mammalian cells

Tag

Flag
GST
His (Fc)
Avi
Myc
DDK
N/A
T7

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SSX4-2975H	Recombinant Human SSX4, GST-tagged	E.coli	GST	1-188aa	$319 / 25ug
Human	SSX4-2967H	Recombinant Human SSX4, T7-tagged	E.coli	T7		Inquiry
Human	SSX4-1444HCL	Recombinant Human SSX4 293 Cell Lysate	HEK293	N/A		Inquiry
Human	SSX4-1445HCL	Recombinant Human SSX4 293 Cell Lysate	HEK293	N/A		Inquiry
Human	SSX4-2504H	Recombinant Human SSX4 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	SSX4-2110H	Recombinant Human SSX4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	SSX4-1341HFL	Recombinant Full Length Human SSX4 Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	SSX4-2110H-B	Recombinant Human SSX4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

SSX4 involved in several pathways and played different roles in them. We selected most pathways SSX4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SSX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

SSX4 has several biochemical functions, for example, nucleic acid binding, transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SSX4 itself. We selected most functions SSX4 had, and list some proteins which have the same functions with SSX4. You can find most of the proteins on our site.

Function	Related Protein
nucleic acid binding	JAZF1;FOXP1B;ZFPM1;AGO3B;SP5L;PRDM12B;ZFP27;ZNF710A;POGZA
transcription corepressor activity	SKOR1B;HDAC3;SKI;NFIL3;SSX3;SMARCA4;CRYM;MYBBP1A;HIPK2

SSX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SSX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SSX4.

HIF1A