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ST5

Official Full Name

suppression of tumorigenicity 5
Overview

This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified.
Synonyms

ST5; suppression of tumorigenicity 5; suppression of tumorigenicity 5 protein; DENN/MADD domain containing 2B; DENND2B; HTS1; p126; DENN domain containing protein 2B; HeLa tumor suppression 1; DENN domain-containing protein 2B; ST 5; ST5_HUMAN;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ST5-1439HCL	Recombinant Human ST5 293 Cell Lysate	HEK293	N/A		Inquiry
Zebrafish	ST5-476Z	Recombinant Zebrafish ST5	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
ST5 Related Articles

ST5 involved in several pathways and played different roles in them. We selected most pathways ST5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ST5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

ST5 has several biochemical functions, for example, Rab guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ST5 itself. We selected most functions ST5 had, and list some proteins which have the same functions with ST5. You can find most of the proteins on our site.

Function	Related Protein
Rab guanyl-nucleotide exchange factor activity	DENND4C;RAB3IL1;DENND1C;ST5;DENND6B;DENND5A;RIN3;FAM116B;SBF1

ST5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ST5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ST5.

ABL1; SFN; GRB2; SMAD2; recC; Flot1; MYH9; Actb; PPP1CB; Myh10; LLGL2; Myh9; MYO18A; MYO19; Calml3; ANLN; Myo1c; Coro1c

Korkmaz, GA; Al, FD; et al. Investigation of the Presence of Blastocystis spp. in Stool Samples with Microscopic, Culture and Molecular Methods. MIKROBIYOLOJI BULTENI 49:85-97(2015).

SATO, S; TAKAMATSU, N; et al. CONSTRUCTION OF MUTANTS OF ACTINOBACILLUS-ACTINOMYCETEMCOMITANS DEFECTIVE IN SEROTYPE-B-SPECIFIC POLYSACCHARIDE ANTIGEN BY INSERTION OF TRANSPOSON TN916. JOURNAL OF GENERAL MICROBIOLOGY 138:1203-1209(1992).