STAT1
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Official Full Name
signal transducer and activator of transcription 1, 91kDa
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Overview
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors,;STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that;translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various;ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a;variety of genes, which is thought to be important for cell viability in response to different cell stimuli and;pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. -
Synonyms
STAT1; signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1-alpha/beta; ISGF 3; STAT91; transcription factor ISGF 3 components p91/p84; transcription factor ISGF-3 components p91/p84; signal transducer and activator of transcription-1; CANDF7; ISGF-3; DKFZp686B04100;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Sf21 Insect Cell
- Sf9 Insect Cell
- Flag
- GST
- His
- His (Fc)
- Avi
- His|MBP
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- STAT1 Related Articles
- STAT1 Related Gene Family
- STAT1 Related Research Area
- STAT1 Related Signal Pathway
STAT1 involved in several pathways and played different roles in them. We selected most pathways STAT1 participated on our site, such as Chemokine signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | CXCL9;CCL13;CCL27;STAT5B;GRK1;FGR;GNG4;XCL2;CCL22 |
| Osteoclast differentiation | SIRPG;FCGR2B;AKT1;IL1A;PPP3CA;SFPI1;NFATC2;MAPK9;CYLD |
| Toll-like receptor signaling pathway | IRF3;IKBKG;TLR3;IFNA6;AKT1;MAPK3;PIK3CG;NFKBIA;TLR2-1 |
| Jak-STAT signaling pathway | IFNAR1;PTPN2;CTF1;LEP;GFAP;PIK3R3;AOX2P;FHL1A;IFNA7 |
| Prolactin signaling pathway | SOCS5;MAPK13;MAPK11;IRF1;SOCS3;PPIB;STAT5A;SOS1;ESR2 |
| Thyroid hormone signaling pathway | PIK3CD;ESR1;PLCB4;ATP1B1;ATP2A2;DIO1;SLC2A1;PLCB1;DIO2 |
| Leishmaniasis | HLA-DQB1;IFNG;HLA-DMB;IL12A;HLA-DRA;IRAK4;HLA-DRB1;PTGS2;TLR2 |
| Toxoplasmosis | MAP3K7;RELA;NFKB1;HSPA8;ALOX5;MAPK9;ITGA6;LAMB2;PIK3CA |
| Tuberculosis | TRAF6;IFNA5;PLK3;TLR2;RAB5C;H2-AA;CORO1A;IRAK1;NFKB1 |
| Hepatitis C | HRAS;IFNA16;MAVS;IKBKG;CLDN6;BRAF;MAPK13;PPP2CA;CLDN20 |
| Hepatitis B | IFNAR1;MAP3K1;IFNA1;IRF3;GRB2;RB1;SRC;TLR4;TNF |
| Measles | STAT5B;TBK1;IFNB1;PIK3R5;Il2;IL1A;HSPA1L;IKBKE;IFIH1 |
| Influenza A | TMPRSS13;IFNA14;CXCL8;NXT1;MAPK10;IVNS1ABP;IL6;Ifna15;H2-AA |
| Herpes simplex infection | PML;CASP3A;SRSF3;BMA2;MAPK8B;BLB2;TLR3;H2-AA;CD74A |
| Pathways in cancer | TCEB2;FADD;GRB2;FGF10;RXRG;FGF11;WNT7B;RUNX1T1;PLD1 |
| Pancreatic cancer | TGFB2;TRP53;RALGDS;RAC3;KRAS;IKBKG;BAD;MAPK10;PIK3CD |
| Inflammatory bowel disease (IBD) | Il2;IL23R;IL5;HLA-DQB1;IL22;IL17F;HLA-DMB;SMAD2;RELA |
STAT1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by STAT1 itself. We selected most functions STAT1 had, and list some proteins which have the same functions with STAT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
STAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAT1.
STAT2; IFNGR1; EGFR
- Q&As
- Reviews
Q&As (6)
Ask a questionSTAT1 is a signal transduction and transcriptional activator involved in regulating a variety of biological processes such as cell growth, differentiation, apoptosis, and immune response.
Mutations in the STAT1 gene have been found to be associated with a variety of diseases, including autoimmune diseases, primary immunodeficiency diseases, and malignant tumors.
The STAT1 protein is primarily activated by the JAK-STAT signaling pathway. When activated by the receptor, JAK kinase phosphorylates the STAT1 protein, allowing it to form dimers and enter the nucleus to regulate transcription of related genes.
The STAT1 protein plays an important role in many diseases, including tumors, immune-related diseases (such as immunodeficiency diseases, autoimmune diseases), infectious diseases (such as viral infections), etc.
Some activators or inhibitors of the STAT1 protein have been identified. These compounds can be used to study the function of the STAT1 protein and the development of disease treatments.
The STAT1 protein plays an important role in viral infection. It mediates interferon signaling, promotes antiviral immune responses, and inhibits viral replication and transmission.
Customer Reviews (3)
Write a reviewIt is well suited for our laboratory to induce specific immune responses.
It has great application potential and performs well in all aspects.
This protein has high yield and high purity, which greatly improves our production efficiency.
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