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STC2

  • Official Full Name

    stanniocalcin 2

  • Overview

    This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.
  • Synonyms

    STC2; stanniocalcin 2; stanniocalcin-2; STC 2; STC-related protein; stanniocalcin-related protein; STC-2; STCRP;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • DDK|His
  • Fc|His
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human STC2-3746H Recombinant Human STC2 protein, Flag-tagged HEK293 Flag
Human STC2-142H Recombinant Human Stanniocalcin 2, Flag-tagged HEK293 Flag
Human STC2-201H Recombinant Human Stanniocalcin 2, T7-tagged E.coli T7
Human STC2-187H Recombinant Human STC2, His tagged Human Cell Fc/His
Human STC2-30114TH Recombinant Human STC2, FLAG-tagged Flag
Human STC2-30113TH Recombinant Human STC2, T7 -tagged E.coli T7
Human STC2-7631H Recombinant Human STC2, His-tagged E.coli N/A 25-302aa
Human STC2-519H Recombinant Human STC2 Protein, DDK/His-tagged HEK293 DDK/His
Human STC2-8603H Recombinant Human STC2, Fc tagged Human Cell N/A
Human STC2-849HCL Recombinant Human STC2 cell lysate Human Cell N/A
Human STC2-373H Recombinant Human STC2 Protein, His-tagged E.coli His Ile53~Gln294
Human STC2-2895H Recombinant Human STC2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human STC2-313H Recombinant Human STC2 protein, GST-tagged E. coli GST 11-291 aa
Human STC2-3028H Recombinant Human STC2 protein, His-tagged E.coli His 121-302 aa
Human STC2-0256H Recombinant Human STC2 protein, His-tagged HEK293 His Met1-Arg302
Human STC2-6650H Recombinant Human STC2 Protein (Ile53-Gln294), His tagged E.coli His Ile53-Gln294
Mouse STC2-16118M Recombinant Mouse STC2 Protein Mammalian Cell His
Mouse STC2-8793M-B Recombinant Mouse STC2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Stc2-6176M Recombinant Mouse Stc2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse STC2-8793M Recombinant Mouse STC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Stc2-4574M Recombinant Mouse Stc2 protein E.coli N/A 25-296aa
Rat STC2-5784R Recombinant Rat STC2 Protein Mammalian Cell His
Rat STC2-5443R-B Recombinant Rat STC2 Protein Pre-coupled Magnetic Beads HEK293
Rat STC2-5443R Recombinant Rat STC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • STC2 Related Articles

STC2 involved in several pathways and played different roles in them. We selected most pathways STC2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with STC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

STC2 has several biochemical functions, for example, enzyme binding, heme binding, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by STC2 itself. We selected most functions STC2 had, and list some proteins which have the same functions with STC2. You can find most of the proteins on our site.

Function Related Protein
enzyme bindingAPOA5;KDM1A;USP22;STUB1;RPS2;EIF2AK3;SCN5A;PRMT1;Txn1
heme bindingCYP46A1;CYP27A1;IDO1;CYP3A25;NENF;CYP2AA9;CYP3A4;CYP2E1;CYB5R4
hormone activityPRLH;FSD1;ADM2;RETNLB;PRL2;ADCYAP1A;GNRH2;PRL2A1;CRHB
protein homodimerization activityZNF174;CRYBA2;SLC22A6;ENG;PRLR;SDS;RELA;APOC2;BMP4

STC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of STC2.

ADAM11; AIFM1; POLR2C; PTN; PEBP1; ARRB2; PPP1R8; ARHGEF40; POLR3F; EIF2B3; CARHSP1

Miyazaki, S; Kikuchi, H; et al. Anti-VEGF antibody therapy induces tumor hypoxia and stanniocalcin 2 expression and potentiates growth of human colon cancer xenografts. INTERNATIONAL JOURNAL OF CANCER 135:295-307(2014).
Kashyap, MK; Pawar, HA; et al. Evaluation of protein expression pattern of stanniocalcin 2, insulin-like growth factor-binding protein 7, inhibin beta A and four and a half LIM domains 1 in esophageal squamous cell carcinoma. CANCER BIOMARKERS 12:1-9(2012).
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