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STEAP2

Official Full Name

STEAP family member 2, metalloreductase
Overview

This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Synonyms

STEAP2; STEAP family member 2, metalloreductase; PCANAP1, prostate cancer associated protein 1 , six transmembrane epithelial antigen of the prostate 2; metalloreductase STEAP2; IPCA 1; STAMP1; STMP; prostate cancer associated protein 1; prostate cancer;

Type

Recombinant Proteins

Species

Homo sapiens (Human)
Human
Mus musculus (Mouse)

Source

E.coli
E.coli expression system
HEK293
In Vitro Cell Free System
In vitro E. coli expression system
Wheat Germ

Tag

GST
His
SUMO
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	STEAP2-29478H	Active Recombinant Human STEAP2 Full Length Transmembrane protein(Nanodisc)	HEK293	N/A		Inquiry
Human	STEAP2-3001H	Recombinant Human STEAP2, His-tagged	E.coli	His	155-265aa	$319 / 25ug
Human	STEAP2-15H	Recombinant Human STEAP2 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	STEAP2-16H	Recombinant Human STEAP2 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	STEAP2-2454H	Recombinant Human STEAP2 Full Length Transmembrane protein, His-SUMO-tagged	In vitro E. coli expression system	His-SUMO	1-490aa	Inquiry
Human	STEAP2-649HF	Recombinant Full Length Human STEAP2 Protein, GST-tagged	In Vitro Cell Free System	GST	490 amino acids	Inquiry
Homo sapiens (Human)	RFL23588HF	Recombinant Full Length Human Metalloreductase Steap2(Steap2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-490aa)	Inquiry
Mus musculus (Mouse)	RFL27667MF	Recombinant Full Length Mouse Metalloreductase Steap2(Steap2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-489)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
STEAP2 Related Articles

STEAP2 involved in several pathways and played different roles in them. We selected most pathways STEAP2 participated on our site, such as Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with STEAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Mineral absorption	TF;SLC11A1;SLC11A2;SLC26A9;TRPV6;SLC40A1;CLCN2;MT1F;ATP1B2

STEAP2 has several biochemical functions, for example, cupric reductase activity, ferric-chelate reductase (NADPH) activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STEAP2 itself. We selected most functions STEAP2 had, and list some proteins which have the same functions with STEAP2. You can find most of the proteins on our site.

Function	Related Protein
cupric reductase activity	STEAP2;STEAP4;STEAP3
ferric-chelate reductase (NADPH) activity	STEAP4;STEAP3;STEAP2
metal ion binding	ZNF497;ZFP523;CYP2Y3;NUDT12;TESK2;RNF11B;ZFP687;ZFP524;PRKRIR
transporter activity	AQP10B;TMEM184B;AQP11;TIMM9;SLC2A3A;PTGDSA;SLC16A10;ABCB8;ABCA1B

STEAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STEAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of STEAP2.

Grunewald, TGP; Bach, H; et al. The STEAP protein family: Versatile oxidoreductases and targets for cancer immunotherapy with overlapping and distinct cellular functions. BIOLOGY OF THE CELL 104:641-657(2012).

McCarthy, RC; Kosman, DJ; et al. Mechanistic analysis of iron accumulation by endothelial cells of the BBB. BIOMETALS 25:665-675(2012).

Vaghjiani, RJ; Talma, S; et al. Six-Transmembrane Epithelial Antigen of the Prostate (STEAP1 and STEAP2)-Differentially Expressed by Murine and Human Mesenchymal Stem Cells. TISSUE ENGINEERING PART A 15:2073-2083(2009).